63. Protein Dysregulation in Neurodegenerative Disorders (with Dr. Estella Newcombe)

Neuroverse

In this episode, we are joined by a special guest, Dr. Estella Newcombe, to discuss protein dysregulation in neurodegenerative disorders.

Estella is currently a Marie Sklodowska-Curie Fellow at the University of Copenhagen in the structural biology and NMR laboratory, researching intrinsically disordered proteins in the context of neurodegenerative disorders. Estella holds a Bachelor’s degree in Biotechnology and Chemistry from the University of Queensland and a PhD in Biochemistry and Molecular Biology from the University of Melbourne, where she studied the interactions and structures of proteins in Huntington’s disease. She subsequently worked as a postdoctoral fellow at the Queensland Brain Institute studying the structures of intrinsically disordered proteins. Based on her wide range of experience in the fields of structural protein biology and neuroscience, in this episode we discuss the value of studying human neurodegenerative disorders at the level of protein-protein interactions. We cover what intrinsically disordered proteins are, the relevance of structure-function relationships, and how environmental factors influence protein dysfunction in neurodegeneration.

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