Cryo-Electron Microscopy and the Resolution Revolution

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In this episode, recorded in-person on February 4, 2020, we talked to a team of Penn State researchers and about the stunning advancements made in recent years in the field of electron microscopy.

Up for discussion was a short history of electron microscopy, including how the addition of cryogenics has enabled new materials and structures to be imaged, and how breakthroughs in certain scientific fields have enabled advances in some very different disciplines. We also talked about how Penn State has robustly supported the development of cryo-EM and leveraged its advantage to create a world-class instrumentation facility.

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  • Deb Kelly is Professor of Biomedical Engineering and Director of the Center for Structural Oncology at Penn State. Her research involves the innovative use of cryoelectron microscopy and in situ transmission electron microscopy to deeply investigate the tiniest of biological structures. Dr. Kelly's mission is to engineer new molecular paradigms to create a world without cancer.
  • Jennifer Gray is an assistant research professor and staff scientist at Penn State's Materials Research Institute, specializing in transmission electron microscopy and cryoelectron microscopy. As a highly specialized technologist working at the convergence of materials and life sciences, Gray helps researchers from both camps to benefit from the breakthroughs made by the other.
  • Cameron Varano is Assistant Research Professor of Biomedical Engineering at Penn State. Her research in structural biology involves prolific use of cryoelectron microscopy to examine and categorize exosomes involved in the development of metastatic cancer.

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