#610: The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More
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The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More | Brought to you by Levels real-time feedback on how diet impacts your health, Athletic Greens all-in-one nutritional supplement, and LMNT electrolyte supplement. More on all three below.
Dr. Matt Kaeberlein (@mkaeberlein) is a professor of Laboratory Medicine and Pathology at the University of Washington School of Medicine, with adjunct appointments in Genome Sciences and Oral Health Sciences. Dr. Kaeberlein’s research interests are focused on understanding biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life for people and companion animals.
Dr. Kaeberlein is the founding director of the University of Washington Healthy Aging and Longevity Research Institute, the director of the NIH Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington, director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-director of the Dog Aging Project.
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[06:44] What is aging biology?
[08:43] How Matt pivoted from mathematics to biology.
[11:46] What is the Dog Aging Project?
[13:42] Understanding healthspan through Matt’s frozen shoulder ordeal.
[20:23] Rapamycin vs. sterile inflammation.
[23:07] Current thoughts about how the immune system changes as we age.
[29:11] Anti-aging uses for rapamycin (and potential risks/side effects).
[42:20] Rapamycin and the Dog Aging Project.
[45:30] Rapamycin vs. neurodegeneration.
[48:21] What studies tell us about rapamycin’s potential to increase lifespan.
[51:30] Rapamycin alternatives considered for the Dog Aging Project.
[57:05] Urolithin A and spermidine.
[59:45] 17 alpha estradiol.
[1:03:54] NAD precursors.
[1:05:52] What is Matt doing to increase his own lifespan/healthspan?
[1:09:00] Is time-restricted feeding beneficial for dogs?
[1:17:08] Currently, how well (or poorly) funded is longevity research?
[1:22:02] Where additional funding in this field would be best leveraged.
[1:35:19] Cutting through the hype and snake oil.
[1:45:24] NAD infusion vs. natural NAD replenishment.
[2:08:58] Is there a fix to liability in defensive medicine?
[2:10:48] Finding better motivations for scientific pursuit.
[2:15:48] Longevity scientists worth checking out.
[2:17:39] Getting involved with the Dog Aging Project / parting thoughts.
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Past guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more.