Impactful malaria science, and the trailblazers leading the fight. A podcast from the Johns Hopkins Malaria Research Institute.
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In this podcast, Silas Majambere discusses with various experts the issues of inequity in global health and in particular the inadequacy of malaria control strategies in Africa. Silas Majambere is a Public Health Entomologist who has spent 20 years of his career studying and fighting mosquitoes that transmit malaria. If you are interested in global health equity, and the intricacies of poverty and international aid, this podcast is for you.
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The podcast that brings you closer to the malaria experts. From researchers to policy creators, everyone will be heard. A podcast by Fight Malaria.
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The Malaria Minute podcast brings you global malaria news in 60 seconds. Updated weekly. A podcast by Fight Malaria.
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This is part 2 of a two-part series dedicated exclusively to The Pan-African Mosquito Control Association – PAMCA. We discuss the issues around the legality of the current board, and the rumors of financial mismanagement inside PAMCA.Bởi Silas Majambere
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Malaria Advocacy on Capitol Hill: Funding, Research, and Global Impact
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15:53The podcast explores the importance of advocacy for malaria research and control. It follows over 120 advocates gathering in Washington, DC, as part of the ‘United to Beat Malaria’ campaign, urging Congress to continue supporting global malaria efforts. Key topics include: The US President’s Malaria Initiative (PMI), founded in 2005, which provides…
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EXTENDED: AI-Driven Malaria Control – Neural Networks and the Task-Shifting of Vector Surveillance (with Soumya Acharya and Sunny Patel)
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12:48With a shortage of entomologists in malaria-endemic regions, could AI fill the gap? We explore VectorCam, an offline tool powered by a Convolutional Neural Network that aims to support local vector surveillance. with Dr. Soumya Acharya and Sunny Patel of Johns Hopkins University. About The Podcast The Johns Hopkins Malaria Minute is produced by the…
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The Pan-African Mosquito Control Association (PAMCA) has been going through a leadership and management crisis for 2 years now. In this first part of a two-part series, I have invited four guests, who have worked for PAMCA for several years, to discuss how PAMCA was organized and what brought it to the current stalemate.…
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VectorCAM: The AI Tool Improving Mosquito Detection
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1:22Can AI identify mosquito species? VectorCAM, a pocket-sized device, uses machine learning to differentiate species with 95% accuracy, enhancing malaria surveillance efforts Transcript Not all mosquitoes are created equal. Of the more than three thousand species, only a limited number of the Anopheles genus can transmit malaria. Even within that sub…
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EXTENDED: Could a Juice Pouch Revolutionize Mosquito Control? (with George Dimopoulos)
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9:21For decades, insecticides have shielded us from malaria—but cracks are showing. Resistance is spreading, and environmental concerns are growing. Could a simple pouch of fruit juice with a powerful secret be the breakthrough we need? with George Dimopoulos of the Johns Hopkins Malaria Research Institute About The Podcast The Johns Hopkins Malaria Mi…
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One of the main ways of controlling malaria is to reduce mosquito populations through insecticides. But the mosquitoes are developing resistance, making most insecticides less effective. What if the answer lies beneath our feet? Transcript One of the main ways of controlling malaria is to reduce mosquito populations through insecticides. But the mo…
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EXTENDED: Mapping Social Networks to Strengthen Malaria Prevention (with András Vörös and Elisa Bellotti)
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12:13The prevention of malaria depends upon multiple layers of interventions that work together to reduce cases and deaths. But what makes someone decide to sleep under a bed net, or apply an insecticidal cream? What makes one person take up more interventions than another? How influential are government-accredited health experts versus friends and fami…
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How Conversations Shape Malaria Prevention Practices
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1:25Malaria prevention depends on the adoption of multiple behaviors – like sleeping under a bednet and wearing clothes that cover the skin. Researchers find that conversations with people in one’s own social circle are the strongest factors that influence behavior uptake. Transcript Malaria prevention depends on the adoption of multiple behaviors – li…
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EXTENDED: Discovering New Targets for Malaria Vaccines and Monoclonal Antibodies (with Joshua Tan)
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8:47Today, the discovery of antibodies targeting a new region of the malaria parasite that could serve as a promising target for drugs and vaccines.
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Scientists Uncover 'Site of Vulnerability' in Malaria Parasites
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1:29Scientists discover new antibodies - a promising target for clinical exploration. Transcript The currently licenced malaria vaccines and monoclonal antibodies all target a well-known region of the same malaria protein. That protein – the circumsporozoite protein, commonly known as CSP – covers the surface of the parasite as it enters the human skin…
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EXTENDED: How AI Chatbots Could Help Predict Antimalarial Drug Resistance Before It Strikes (with Robert Opoka and Elizabeth Winzeler)
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12:31We focus on drug resistance and the troubling news that the frontline drug against malaria, artemisinin, is failing due to resistant parasites in severe cases of malaria, and how the collective efforts of drug development – and the data produced – could be used to build an AI chatbot capable of predicting resistance before it strikes. With Robert O…
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How to Predict (And Avert) Antimalarial Drug Resistance
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1:16Researchers search for ways to predict antimalarial drug resistance and identify more effective drug combinations. Transcript The front-line treatment for malaria is typically a combination of drugs called artemisinin-based combination therapy. Resistance to treatment has already been reported in mild cases of malaria, but now, for the first time, …
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‘Big Push’ Needed to Turn Tide on Malaria – WHO
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1:23The World Health Organization has today released its annual World Malaria Report. Here are the takeaways. Transcript The World Health Organization has today released its annual World Malaria Report. Here are the takeaways. Since the turn of the century, the global malaria community has averted over 2.2 billion malaria cases and 12.7 million deaths,…
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EXTENDED: Listening to Malaria – How Lasers and Ultrasound Could Revolutionize Diagnosis (with Sunil Parikh, Vladimir Zharov and Yap Boum)
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11:43An innovative, non-invasive diagnostic tool that could revolutionize malaria testing, with the potential to be built into wearable devices. In this extended episode of the Johns Hopkins Malaria Minute, we ask: What are the limitations of current malaria diagnostic methods? How is a 'cytophone' - and what makes it innovative? Why is the detection of…
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The Skin-Contact Malaria Test That Could Revolutionize Diagnostics
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1:10Using lasers and ultrasound, the ‘cytophone’ detects a key byproduct of all malaria parasites. Transcript Among the most commonly used malaria diagnostic tests is the rapid diagnostic test (RDT), which detects malaria antigens from a drop of blood. Whilst RDTs are small and cheap, they're invasive and new strains of the parasite have evolved that c…
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There are many reasons to lose hope. But you can choose to remain hopeful. Here are my reasons.Bởi Silas Majambere
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EXTENDED: First Reference Genome Sequence of P. vivax from Ethiopia (with Jane Carlton, Delenasaw Yewhalaw, and Francisco Callejas Hernandez)
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8:59Today, how DNA from a single patient in Ethiopia can shed light on the big picture of malaria. Why is Plasmodium vivax significant in malaria research, especially in Ethiopia? How does genomic sequencing contribute to understanding and controlling malaria? How are advances in sequencing technology influencing malaria research? With Jane Carlton, De…
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How Comparative Genomics Can Help Find the Best Treatments for Malaria
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1:13'Comparative genomics' helps identify genes that can serve as targets for future drugs and vaccines. Transcript Not all parasites are alike. Genetic mutations mean that malaria parasites evolve differently in different regions – and even within the same region. One species thought to be particularly genetically diverse is Plasmodium vivax. It’s the…
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EXTENDED: The Surprising Advantage of Transmission-Blocking Vaccines (with Ilinca Ciubotariu, Qixin He and Giovanna Carpi)
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9:22The World Health Organisation has recommended two licenced malaria vaccines. Those vaccines have been a long time coming - but are they the best? In this extended episode of the Johns Hopkins Malaria Minute, we ask: Why is developing a malaria vaccine so challenging? How does antigen variation play affect the effectiveness of malaria vaccines? What…
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Transmission-Blocking Antigens Show Low Variation, Making Them a Reliable Vaccine Target Across Countries
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1:14A key challenge in developing a malaria vaccine is choosing which stage to target. Transcript A key challenge in developing a malaria vaccine is choosing which stage of the infection to target. You can target the parasite when it enters the body, multiplies in the liver and the blood, or is in the sexual stage, preparing to be picked up by a mosqui…
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EXTENDED: World Mosquito Day - Gene Drives and CRISPR Technology
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13:19We share a special episode of our podcast to mark World Mosqutio Day. World Mosquito Day, observed annually on August 20th, commemorates British doctor Sir Ronald Ross's discovery in 1897 that female Anopheles mosquitoes transmit malaria to humans. More than a century later, major advancements like genetically modifying mosquitoes—AKA gene drives—h…
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Gene Drives: A Sharper Tool for the Malaria Toolkit?
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1:15People often talk about the 'malaria toolkit' - how might gene drives fit? Transcript When people talk about malaria, they often mention the 'malaria toolkit' – a set of tools, like bed nets and indoor residual spraying, that are available to help curb the spread of disease. In the past, these tools were trusty go-to's – thanks to their efficacy, s…
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EXTENDED: CRISPR and Consent (Gene Drives Part I - with Anthony James and John Connolly)
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12:24Gene drives are a novel way of genetically editing the mosquitoes that transmit malaria. They have the potential to dramatically reduce cases and deaths. But the technology they’re based on is new and requires new thinking on regulation. In this first episode of our two-part focus on gene drives, we ask how drives work – examining the CRISPR techno…
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Gene drives are a promising tool for malaria control - how can we tell they actually work? Transcript Gene drives are a promising new tool for malaria control. They involve releasing genetically modified mosquitoes into the wild – mosquitoes engineered to halt the parasites from developing inside the insects, or that cause the mosquitoes to die. Th…
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EXTENDED: How Climate Change Could Lead To Faster, More Intense Malaria Transmission (with Alex Eapen)
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7:07Temperature, rainfall, and humidity determine malaria transmission - but climate change is altering each one of those variables. What might this mean for cases of the disease? With Alex Eapen, from the ICMR (Indian Council of Medical Research) in Chennai, India. About The Podcast The Johns Hopkins Malaria Minute is produced by the Johns Hopkins Mal…
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Increase in Temperature Associated With Decrease in Incubation Period
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1:21Researchers compare the temperature of mosquito breeding spots with a decade early to examine its impact on malaria transmission. Transcript The effects of climate change on malaria are becoming clearer. Anopheles stephensi – an urban form of the malaria mosquito – is changing its geography, moving from Southeast Asia to parts of Africa and India. …
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EXTENDED: Investigating PfHDAC1 – The Essential Malaria Protein Behind Human Sickness (with Abhishek Kanyal and Krishanpal Karmodiya)
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11:04A single protein helps malaria parasites develop in the blood and cause disease symptoms. Could inhibiting this essential protein help curb the spread of disease? With Abhishek Kanyal and Krishanpal Karmodiya. About The Podcast The Johns Hopkins Malaria Minute is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malari…
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Blood-Stage Protein Identified as Key Target for Antimalarial Drugs
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1:16A poorly studied malaria protein could serve as a key drug target to help combat the growing problem of resistance. Transcript A poorly studied malaria protein – Plasmodium falciparum histone deacetylase 1 – could serve as a key drug target to help combat the growing problem of resistance. The protein helps regulate the ‘intraerythrocytic’ stage of…
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#11 A conversation with Dr Fitsum Tadesse, Lead Scientist at AHRI in Ethiopia
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59:57Dr Fitsum Tadesse is a Lead Scientist at the Armauer Hansen Research Institute (AHRI) in Ethiopia, a Wellcome Trust Fellow at LSHTM and an Alan J. Magill Fellow at ASTMH His work mainly focuses on the transmission of malaria parasites from humans to mosquitoes. His group recently demonstrated the contribution of the invasive mosquito, Anopheles ste…
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EXTENDED: What Sickle Cell Disease Reveals About Malaria and Human Evolution
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8:32How sickle cell disease can be a blessing and a curse. And why we need equity in genomic research and to diversify the genomes we sequence. With Ambroise Wonkam (Johns Hopkins University). About The Podcast The Johns Hopkins Malaria Minute is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to sha…
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The Malaria Legacy of Sickle Cell Disease
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1:18Malaria is one of humanity’s oldest diseases – and one with which we have evolved. Transcript Malaria is one of humanity’s oldest diseases – and one with which we have evolved. Over time, it’s put selective pressure on our genome to respond better to its infection. Sickle cell disease is one example. It causes a defect in hemoglobin – transforming …
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#10 A Conversation with Dr Anne Gasasira, Senior Programme Officer at the African Leaders Malaria Alliance
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1:09:05Dr Anne Gasasira is a Ugandan trained medical doctor and epidemiologist. She started her career in malaria and HIV research in the early 2000s. She worked on a research collaboration between Makerere University- University of California San Francisco on antimalarial drug efficacy and HIV–Malaria interaction studies. Since 2015, has been working wit…
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EXTENDED: From Lab to Legislature – Meet the Scientists Taking on Capitol Hill in the Fight Against Malaria
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12:04On the steps of Capitol Hill, we meet the scientists bringing their scientific battle against malaria into the world of political advocacy. They join a 100+ group of advocates lobbying their members of Congress to fund critical interventions against malaria – becoming ‘malaria champions’ as well. We ask: Why have they decided to join the world of p…
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Advocacy on Capitol Hill: Uniting Scientific Research and Policy in the Fight Against Malaria
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1:17Malaria champions from 43 states gather in Washington D.C. to lobby their members of Congress about malaria. Transcript The malaria community is diverse. Some work on the parasites, others the mosquito. Others still focus on public health. The battle is being waged on the bench and the field. But there's another community fighting the disease on a …
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EXTENDED: Odisha's Innovative Approach to Controlling Malaria in Hard-to-Reach Villages (with Praveen Sahu and Jane Carlton)
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7:56Until recently, health workers were the only means to prevent and treat malaria in Odisha, India. In 2017, the state government tried a new strategy: pooling health resources into regional ‘malaria camps’. In this podcast, we ask: What is the current state of malaria in Odisha, India? What challenges does Odisha face in malaria control, especially …
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‘Malaria Camps’ to Control Malaria in Remote Parts of India
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1:42Malaria in India has fallen in recent decades — but the risk is still high among hard-to-reach communities. A new study has evaluated the system of ‘malaria camps’ — in which health workers provide targeted interventions before the monsoon. Transcript Malaria in India has diminished in past decades — yet the risk is still high among hard-to-reach c…
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EXTENDED: Behind the Scenes with a Documentary Crew Following the Malaria Vaccine from Trial to Approval (with Catherine Gale and Bill Moss)
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12:38A new documentary tells a story of global scientific collaboration in the development of a new malaria vaccine, R21. Today, we take you behind the scenes with director and producer, Catherine Gale. In this podcast, we ask: Why are malaria vaccines gaining so much attention now? What was the serendipidous origin of the documentary? What are the key …
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#9. A conversation with Carl Manlan, an Economist working at the intersection of public, private and civil society sectors
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59:59Carl Manlan is an Economist working at the intersection of public, private and civil society sectors. He is a development practitioner with experience in health financing, private foundations, inclusive impact and sustainability.Bởi Silas Majambere
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Documentary Reveals Story of Malaria Vaccine's Creation
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0:59A new documentary from NOVA shines a light on the creation of R21, a new malaria vaccine. Transcript This month, a new documentary from NOVA shines a light on the creation of a new malaria vaccine. ‘The Battle to Beat Malaria’ tells the story of the development of R21 – from creation to WHO approval. Taking you behind the scenes in Oxford, UK, wher…
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#8. A conversation with Sherwin Charles, CEO of Goodbye Malaria
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1:03:40Sherwin Charles is a co-founder and the Chief Executive Officer of Goodbye Malaria, an African initiative to eliminate malaria in Southern Africa. In this episode we discuss his journey into the fight against malaria, the role of the private sector and the financing of malaria elimination; the current reliance on commodities and the role of communi…
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EXTENDED: Rising Temperatures and Extreme Weather Events - The Impact of Climate Change on Malaria (With Martin Edlund and Courtney Murdock)
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9:41As COP28 emphasises the human cost of climate change, what will be the impact of rising temperatures and extreme weather events on malaria transmission? In this podcast, we ask: How was health represented this year at COP? What is the impact of rising temperatures on malaria? How will extreme weather events, like flooding, affect malaria prevalence…
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Climate Change Threatens Malaria Progress – WHO Report
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1:25The WHO launches its annual World Malaria Report at COP28, the UN's Climate Change Conference. Transcript The World Health Organization (WHO) has released its World Malaria Report for 2023 at the start of COP28, the UN’s Climate Change Conference. The headline figures are concerning. The WHO estimates that there were 249 million cases of malaria la…
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#7. A conversation with Dr Michael Charles, CEO of RBM Partnership To End Malaria
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51:20Dr Michael Adenkule Charles is the CEO of the RBM Partnership to End Malaria. He is at the forefront of convening and collaborating with over 500 partners, in the combined mission towards the elimination of malaria. In this episode, I chat with Dr Charles about the issues of localization and agenda setting for malaria elimination in Africa; the ove…
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EXTENDED: The ‘Chemical Vaccine’ for Long-Lasting Malaria Prevention (with Theresa Shapiro)
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8:40An old malaria drug gets a new formulation. But how good is it – and will it drive resistance? In this podcast, we ask: What are the limitations of current malaria vaccines? What is the concept of long-acting injectable (LAI) drugs? What are the clinical and chemical properties of atovaquone that make it suitable for this purpose? With Theresa Shap…
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Turning Drugs Into Vaccines to Offer Longer-Term Protection Against Malaria
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1:08How ‘chemical vaccines’ could offer long-term protection against malaria in endemic areas, and combat the problems of dosing and drug resistance. Transcript Drugs used to prevent and treat malaria are vital tools in the malaria toolkit – but they aren’t perfect. When used to prevent malaria, people must remember to take them regularly, or they won’…
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EXTENDED: How Blood Spots are Mapping Artemisinin Resistance (with Didier Ménard)
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7:06Drug efficacy studies are revealing the spatial distribution of mutations causing artemisinin resistance - and it all starts with a drop of blood. In this podcast, we ask: What is artemisinin resistance? What are some of the key molecular markers underpinning it? How can we overcome it? With Didier Ménard, Director of the Institute of Parasitology …
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#6. My take on the 9th PAMCA annual conference
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11:32In this monologue, I will talk about five positive things I saw during the 9th annual conference of the Pan-African Mosquito Control Association, and four things I have questions about.Bởi Silas Majambere
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Is Artemisinin Drug Resistance in Africa on the Rise?
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1:08Researchers examine the rise of artemisinin drug resistance in Eritrea - and search for its genetic basis. Transcript Artemisinin – a key antimalarial drug – and other drugs derived from it, are fast losing their effectiveness across South East Asia and increasingly in Africa, too. To investigate this, researchers conducted a review of drug efficac…
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Mentors are instrumental in the professional and personal growth of healthcare professionals. However, mentoring relationships often fail to realize their full potential. Attendees will be encouraged and equipped to initiate mentoring relationships that provide both mentor and mentee with a rewarding experience.…
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