133: Clinical Guidance on Neurostimulation for Lennox-Gastaut Syndrome

NeurologyLive® Mind Moments®

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In this episode, epilepsy expert Depobam Samanta, MD, MS, FAAP, FAES, sat down to discuss a recently published guidance paper from members of the Pediatric Epilepsy Research Consortium that provides recommendations for neuromodulation approaches to treat Lennox-Gastaut syndrome (LGS). Samanta, medical director of the Arkansas Children's Comprehensive Epilepsy Program, gave a clinical overview of the paper, highlighting the various neuromodulatory devices and their use, and the ways to improve treatment selection and personalization. Additionally, he talked about some of the potential complications with these devices as well as initiation and titration strategies for easy initiation. Furthermore, he spoke about ways to take neuromodulation to the next level, giving insight on creative trial designs, overcoming sham-controlled studies, and the necessary research to expand these approaches.
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Episode Breakdown:

• 1:05 – Overview of the published guidance and reasons behind the paper
• 5:15 – Patient selection for neuromodulation and tailoring treatments by patient and preference
• 8:25 – Overcoming complications with neuromodulation devices
• 11:25 – Multidisciplinary team necessary for successful implementation of neuromodulation
• 13:15 – Neurology News Minute
• 15:15 – Initiation and titration strategies for vagus nerve stimulation, deep brain stimulation, and resective surgery
• 18:30 – Next steps in research and expanding neuromodulation for patients with LGS
• 21:10 – Finding creative trial designs to test neuromodulation devices, combination approaches

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