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Ep. 11: “Adoptive T Cell Transfer” Featuring Dr. Christopher Klebanoff
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Guest:
Dr. Christopher Klebanoff is a Principal Investigator and Attending Physician at the Memorial Sloan Kettering Cancer Center. His research focuses on cell-based cancer immunotherapies, T cell receptors, and the therapeutic targeting of shared cancer neoantigens. Using single-cell sequencing, biophysical measurements of T cell receptor affinity, genetic engineering, and structural immunobiology, the Klebanoff lab aims to adapt adoptive T cell transfer for advanced solid tumors.
Featured Products and Resources:
The Immunology Science Round Up
Dual Targeting of Tregs – A CTLA-4 antibody combined with a signal regulatory protein modulates both “eat me” and “do not eat me” signals to deplete regulatory T cells in the tumor microenvironment.
A Cell-Free Assay for SARS-CoV-2 Neutralizing Antibodies – Researchers developed a multiplex assay to assess neutralizing antibodies to SARS-CoV-2 variants of concern in convalescent plasma.
T Cells and Oral Vaccines in Environmental Enteric Dysfunction – Scientists developed a mouse model for environmental enteric dysfunction and found impaired CD4+ T cell responses in the small intestine, which reduced oral vaccine efficacy.
Vertical Transfer of Maternal Immune Cells – Maternal microchimeric cells promote fetal immune development and are linked to a lower number of respiratory infections in early life.
Photo Reference: Courtesy of Dr. Christopher Klebanoff
90 tập
Fetch error
Hmmm there seems to be a problem fetching this series right now. Last successful fetch was on April 09, 2024 22:11 ()
What now? This series will be checked again in the next day. If you believe it should be working, please verify the publisher's feed link below is valid and includes actual episode links. You can contact support to request the feed be immediately fetched.
Manage episode 300153330 series 2895470
Guest:
Dr. Christopher Klebanoff is a Principal Investigator and Attending Physician at the Memorial Sloan Kettering Cancer Center. His research focuses on cell-based cancer immunotherapies, T cell receptors, and the therapeutic targeting of shared cancer neoantigens. Using single-cell sequencing, biophysical measurements of T cell receptor affinity, genetic engineering, and structural immunobiology, the Klebanoff lab aims to adapt adoptive T cell transfer for advanced solid tumors.
Featured Products and Resources:
The Immunology Science Round Up
Dual Targeting of Tregs – A CTLA-4 antibody combined with a signal regulatory protein modulates both “eat me” and “do not eat me” signals to deplete regulatory T cells in the tumor microenvironment.
A Cell-Free Assay for SARS-CoV-2 Neutralizing Antibodies – Researchers developed a multiplex assay to assess neutralizing antibodies to SARS-CoV-2 variants of concern in convalescent plasma.
T Cells and Oral Vaccines in Environmental Enteric Dysfunction – Scientists developed a mouse model for environmental enteric dysfunction and found impaired CD4+ T cell responses in the small intestine, which reduced oral vaccine efficacy.
Vertical Transfer of Maternal Immune Cells – Maternal microchimeric cells promote fetal immune development and are linked to a lower number of respiratory infections in early life.
Photo Reference: Courtesy of Dr. Christopher Klebanoff
90 tập
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