NIH Scientists Discuss the iNDI Project for Alzheimer's Disease Modeling

CRISPR Cuts

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Hark | 8 | The Queen's English 29:53

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Living together in a group is a strategy many animals use to survive and thrive. And a big part of what makes that living situation successful is listening. In this episode, we explore the collaborative world of the naked mole rat. Threshold is nonprofit, listener-supported, and independently produced. You can support Threshold by donating today . To stay connected, sign up for our newsletter . Operation frog sound! Send us your frog sounds for an upcoming episode. We want you to go out, listen for frogs and toads, and record them. Just find someone croaking, and hit record on your phone. It doesn’t matter if there’s background noise. It doesn’t even matter if you’re not sure whether or not you’re hearing an amphibian—if you think you are, we would love to get a recording from you. Please also say your name and where you are in the world, and then email the recording to us at outreach@thresholdpodcast.org…

cách đây 4 năm trước 37:14

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The Inducible Pluripotent Stem Cell Neurodegeneration Initiative (iNDI), an NIH effort, aims to standardize disease models for Alzheimer’s and related dementias. Hear the principal contributors, Dr. Michael E. Ward and Dr. Mark R. Cookson, scientists at the NIH, talk about the inception of the iNDI project, the challenges and opportunities, and the future of neurodegenerative research.

44 tập

#Synthego #Biology #Science #Natural Sciences

NIH Scientists Discuss the iNDI Project for Alzheimer's Disease Modeling

CRISPR Cuts

65 subscribers

published cách đây 4 năm trước

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MP3•Trang chủ episode

44 tập

#Synthego #Biology #Science #Natural Sciences

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1
Imran House and Junyun Lai Discuss CRISPR Screening in Immuno-Oncology 26:06

cách đây 1 year trước26:06

26:06

Imran House, Ph.D. and Junyun Lai Ph.D. are Senior Scientists at the biotech start-up, oNKo-Innate in Melbourne, Australia that focuses on developing immuno-oncology therapies. In this episode, they discussed what they do at oNKo-innate, their career transitions from leaving academics to entering the biotech industry, and how CRISPR is impacting cancer-immunotherapy development. They also discussed overcoming common obstacles faced when developing cytokine therapies and future outlooks on clinical trials using these kinds of therapies. Reach out and connect with both Imran and Junyun on social media platforms: Imran House, Ph.D. LinkedIn X: @ImranHouse Junyun Lai, Ph.D. LinkedIn X: @JunyunLai…

1
Mark DeWitt and Don Kohn Discuss Their ex vivo CRISPR-based Therapy to Cure Sickle Cell Anemia 33:24

cách đây 1 year trước33:24

33:24

Dr. Mark DeWitt Ph.D., Associate Director at Mammoth Biosciences, and Dr. Don Kohn M.D., distinguished professor and Director of the UCLA Human Gene and Cell Therapy Program and CIRM grantee sat down with us to discuss their latest clinical trials to cure sickle cell anemia, how synthetic guides accelerated their journey from the bench to the clinic, and their experience in the cell and gene therapy space.…

1
Dina Simkin Breaks Down Epilepsy Cell Modeling 27:24

cách đây 2 years trước27:24

27:24

Dina Simkin, Professor of Neurology at Northwestern University, joins us in this episode of CRISPR Cuts. Dr. Simkin talks about her path to becoming a researcher, art, and the importance of patient and isogenic iPSC models to study genetically linked forms of epilepsies.

1
Sunil Sharma and Raffaella Soldi Talk CRISPR For Unbiased Drug Screening for Rare Pediatric Cancers 24:43

cách đây 2 years trước24:43

24:43

Dr. Sunil Sharma and Dr. Raffaella Soldi of the Translational Genomics Research Institute chat about using CRISPR arrayed screens to identify novel drug targets for Ewing's Sarcoma, outlooks for the future of cancer therapies, and the Arizona heat.

1
Stephanie Cherqui Discusses Clinical Development of CRISPR Therapies for Rare Diseases 20:27

cách đây 2 years trước20:27

20:27

Professor Stephanie Cherqui, UCSD, has worked on the development of cell therapies for two rare genetic diseases, cystinosis and Friedreich’s ataxia. In this interview, Dr. Cherqui chats about her experience working on rare diseases, developing a CRISPR-edited therapy for Friedreich's ataxia, navigating regulatory challenges in cell and gene therapies, and more.…

1
Christian Groendahl On Pioneering a CRISPR-based Microbial Gene Therapy 29:11

cách đây 2 years trước29:11

29:11

Tune in to hear Christian Groendahl, CEO of SNIPR Biome, talk about CRISPR editing in prokaryotes, their novel E. coli- targeting CRISPR therapy trials, and his experiences and vision leading a start up.

1
Bryan Dechairo Envisions an Accessible Future for CRISPR Diagnostics 35:29

cách đây 3 years trước35:29

35:29

In this episode, Bryan Dechairo, CEO of Sherlock Biosciences, talks about the impact of technology advances in the field of CRISPR diagnostics, his experiences leading Sherlock Biosciences, and his team’s mission of accessibility.

1
Ayal Hendel Talks About CRISPR in Bubble Boy Disease 35:46

cách đây 3 years trước35:46

35:46

Dr. Ayal Hendel, a genome-editing pioneer and group leader at Bar Ilan University in Israel, was one of the first researchers to use modified synthetic sgRNA to edit primary cells with CRISPR. In this episode, Dr. Hendel shares his perspectives on the recent CRISPR advancements and his work on the bubble boy disease.…

1
Jimi Olaghere Opens up About His Sickle Cell Disease and CRISPR Trial 39:59

cách đây 3 years trước39:59

39:59

Jimi has dealt with sickle cell disease, a genetic disorder with serious implications, his entire life. Undergoing a CRISPR gene editing trial turned his hope for a cure into reality with promising results from the early phases. Tune in to learn about Jimi's journey in this episode.

1
TJ Cradick Speaks About Their HIV CRISPR Therapy in Trials 23:40

cách đây 3 years trước23:40

23:40

TJ Cradick, Chief Scientific Officer at Excision Bio, discusses their CRISPR HIV therapy that recently proceeded into clinical trials in this episode and their ongoing work on other viral diseases.

1
Bryce Olson Relays His Experience on Personalized Therapies for Cancer Patients 42:37

cách đây 3 years trước42:37

42:37

After being diagnosed with aggressive prostate cancer, Bryce Olson quickly learned the science behind it and has leveraged NGS to understand his tumor genomics and find opportunities in personalized therapies. Hear the patient perspective for the first time on our podcast through Bryce's narration of his experience and pursuit of next generation cell and gene therapies.…

1
Neville Sanjana Discusses Ways to Enhance CRISPR-Cas13 Knockdown in Human Cells 32:52

cách đây 3 years trước32:52

32:52

In this collaboration episode with NEB, we interview Dr. Neville Sanjana, a core faculty member at the New York Genome Center, about his recent publication in which chemically modified guide RNAs were used to enhance CRISPR-Cas13 knockdown in human cells.

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Kiana Aran Chats About her Nature Award and New Non-Profit 41:09

cách đây 3 years trước41:09

41:09

In this episode, we chat with Dr. Kiana Aran, the CSO of Cardea Bio and associate professor at Keck Graduate Institute, who recently won the Nature Research Award for Inspiring Women in Science. Dr. Aran talks about her experience being a nominee and award winner, her early days and scientific journey, and the launch of her new non-profit, Aran Nebula.…

1
6 Women CRISPR Leaders Get Candid About Their Journeys to the Top 1:02:44

cách đây 3 years trước1:02:44

1:02:44

We chatted with six female leaders in the CRISPR—Alison van Eenennaam, Ph.D., Kiana Aran, Christina Trojel-Hansen, Ph.D., Laura Lambert, Ph.D., Elena Miñones Moyano, Ph.D., and Samantha Maragh, Ph.D.— about their professional journeys. Tune in to this episode for a candid and honest discussion on a broad range of topics, including their experiences as women of color, life as working moms, adjusting in male-dominated fields, experiences being part of the LGBTQIA community, and the role of mentors in professional development.…

1
Jesse Boehm Discusses Tackling Rare Cancers Using CRISPR 30:35

cách đây 4 years trước30:35

30:35

In this CRISPR Cuts episode, Dr. Jesse Boehm, the Chief Scientific Officer of the Break Through Cancer Foundation and principal investigator at the Broad Institute, talks about his work on rare cancers. He also covers how CRISPR technology is transforming cancer research.

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CRISPR Cuts « » NIH Scientists Discuss the iNDI Project for Alzheimer's Disease Modeling

NIH Scientists Discuss the iNDI Project for Alzheimer's Disease Modeling

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The Let Them Theory: A Life-Changing Tool That Millions of People Can't Stop Talking About

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The Let Them Theory: A Life-Changing Tool That Millions of People Can't Stop Talking About

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NIH Scientists Discuss the iNDI Project for Alzheimer's Disease Modeling