Show notes are at https://stevelitchfield.com/sshow/chat.html
…
continue reading
Nội dung được cung cấp bởi LessWrong. Tất cả nội dung podcast bao gồm các tập, đồ họa và mô tả podcast đều được LessWrong hoặc đối tác nền tảng podcast của họ tải lên và cung cấp trực tiếp. Nếu bạn cho rằng ai đó đang sử dụng tác phẩm có bản quyền của bạn mà không có sự cho phép của bạn, bạn có thể làm theo quy trình được nêu ở đây https://vi.player.fm/legal.
Player FM - Ứng dụng Podcast
Chuyển sang chế độ ngoại tuyến với ứng dụng Player FM !
Chuyển sang chế độ ngoại tuyến với ứng dụng Player FM !
“Superbabies: Putting The Pieces Together” by sarahconstantin
MP3•Trang chủ episode
Manage episode 429004889 series 3364760
Nội dung được cung cấp bởi LessWrong. Tất cả nội dung podcast bao gồm các tập, đồ họa và mô tả podcast đều được LessWrong hoặc đối tác nền tảng podcast của họ tải lên và cung cấp trực tiếp. Nếu bạn cho rằng ai đó đang sử dụng tác phẩm có bản quyền của bạn mà không có sự cho phép của bạn, bạn có thể làm theo quy trình được nêu ở đây https://vi.player.fm/legal.
This post was inspired by some talks at the recent LessOnline conference including one by LessWrong user “Gene Smith”.
Let's say you want to have a “designer baby”. Genetically extraordinary in some way — super athletic, super beautiful, whatever.
6’5”, blue eyes, with a trust fund.
Ethics aside[1], what would be necessary to actually do this?
Fundamentally, any kind of “superbaby” or “designer baby” project depends on two steps:
1.) figure out what genes you ideally want;
2.) create an embryo with those genes.
It's already standard to do a very simple version of this two-step process. In the typical course of in-vitro fertilization (IVF), embryos are usually screened for chromosomal abnormalities that would cause disabilities like Down Syndrome, and only the “healthy” embryos are implanted.
But most (partially) heritable traits and disease risks are not as easy to predict.
Polygenic Scores
If what you care about is [...]
---
Outline:
(01:16) Polygenic Scores
(03:35) Massively Multiplexed, Body-Wide Gene Editing? Not So Much, Yet.
(06:45) Embryo Selection
(07:52) “Iterated Embryo Selection”?
(09:33) Iterated Meiosis?
(13:29) Generating Naive Pluripotent Cells
(16:50) What's Missing?
The original text contained 5 footnotes which were omitted from this narration.
The original text contained 2 images which were described by AI.
---
First published:
July 11th, 2024
Source:
https://www.lesswrong.com/posts/2uJsiQqHTjePTRqi4/superbabies-putting-the-pieces-together
---
Narrated by TYPE III AUDIO.
---
…
continue reading
Let's say you want to have a “designer baby”. Genetically extraordinary in some way — super athletic, super beautiful, whatever.
6’5”, blue eyes, with a trust fund.
Ethics aside[1], what would be necessary to actually do this?
Fundamentally, any kind of “superbaby” or “designer baby” project depends on two steps:
1.) figure out what genes you ideally want;
2.) create an embryo with those genes.
It's already standard to do a very simple version of this two-step process. In the typical course of in-vitro fertilization (IVF), embryos are usually screened for chromosomal abnormalities that would cause disabilities like Down Syndrome, and only the “healthy” embryos are implanted.
But most (partially) heritable traits and disease risks are not as easy to predict.
Polygenic Scores
If what you care about is [...]
---
Outline:
(01:16) Polygenic Scores
(03:35) Massively Multiplexed, Body-Wide Gene Editing? Not So Much, Yet.
(06:45) Embryo Selection
(07:52) “Iterated Embryo Selection”?
(09:33) Iterated Meiosis?
(13:29) Generating Naive Pluripotent Cells
(16:50) What's Missing?
The original text contained 5 footnotes which were omitted from this narration.
The original text contained 2 images which were described by AI.
---
First published:
July 11th, 2024
Source:
https://www.lesswrong.com/posts/2uJsiQqHTjePTRqi4/superbabies-putting-the-pieces-together
---
Narrated by TYPE III AUDIO.
---
Images from the article:
Apple Podcasts and Spotify do not show images in the episode description. Try Pocket Casts, or another podcast app.
Apple Podcasts and Spotify do not show images in the episode description. Try Pocket Casts, or another podcast app.
351 tập
MP3•Trang chủ episode
Manage episode 429004889 series 3364760
Nội dung được cung cấp bởi LessWrong. Tất cả nội dung podcast bao gồm các tập, đồ họa và mô tả podcast đều được LessWrong hoặc đối tác nền tảng podcast của họ tải lên và cung cấp trực tiếp. Nếu bạn cho rằng ai đó đang sử dụng tác phẩm có bản quyền của bạn mà không có sự cho phép của bạn, bạn có thể làm theo quy trình được nêu ở đây https://vi.player.fm/legal.
This post was inspired by some talks at the recent LessOnline conference including one by LessWrong user “Gene Smith”.
Let's say you want to have a “designer baby”. Genetically extraordinary in some way — super athletic, super beautiful, whatever.
6’5”, blue eyes, with a trust fund.
Ethics aside[1], what would be necessary to actually do this?
Fundamentally, any kind of “superbaby” or “designer baby” project depends on two steps:
1.) figure out what genes you ideally want;
2.) create an embryo with those genes.
It's already standard to do a very simple version of this two-step process. In the typical course of in-vitro fertilization (IVF), embryos are usually screened for chromosomal abnormalities that would cause disabilities like Down Syndrome, and only the “healthy” embryos are implanted.
But most (partially) heritable traits and disease risks are not as easy to predict.
Polygenic Scores
If what you care about is [...]
---
Outline:
(01:16) Polygenic Scores
(03:35) Massively Multiplexed, Body-Wide Gene Editing? Not So Much, Yet.
(06:45) Embryo Selection
(07:52) “Iterated Embryo Selection”?
(09:33) Iterated Meiosis?
(13:29) Generating Naive Pluripotent Cells
(16:50) What's Missing?
The original text contained 5 footnotes which were omitted from this narration.
The original text contained 2 images which were described by AI.
---
First published:
July 11th, 2024
Source:
https://www.lesswrong.com/posts/2uJsiQqHTjePTRqi4/superbabies-putting-the-pieces-together
---
Narrated by TYPE III AUDIO.
---
…
continue reading
Let's say you want to have a “designer baby”. Genetically extraordinary in some way — super athletic, super beautiful, whatever.
6’5”, blue eyes, with a trust fund.
Ethics aside[1], what would be necessary to actually do this?
Fundamentally, any kind of “superbaby” or “designer baby” project depends on two steps:
1.) figure out what genes you ideally want;
2.) create an embryo with those genes.
It's already standard to do a very simple version of this two-step process. In the typical course of in-vitro fertilization (IVF), embryos are usually screened for chromosomal abnormalities that would cause disabilities like Down Syndrome, and only the “healthy” embryos are implanted.
But most (partially) heritable traits and disease risks are not as easy to predict.
Polygenic Scores
If what you care about is [...]
---
Outline:
(01:16) Polygenic Scores
(03:35) Massively Multiplexed, Body-Wide Gene Editing? Not So Much, Yet.
(06:45) Embryo Selection
(07:52) “Iterated Embryo Selection”?
(09:33) Iterated Meiosis?
(13:29) Generating Naive Pluripotent Cells
(16:50) What's Missing?
The original text contained 5 footnotes which were omitted from this narration.
The original text contained 2 images which were described by AI.
---
First published:
July 11th, 2024
Source:
https://www.lesswrong.com/posts/2uJsiQqHTjePTRqi4/superbabies-putting-the-pieces-together
---
Narrated by TYPE III AUDIO.
---
Images from the article:
Apple Podcasts and Spotify do not show images in the episode description. Try Pocket Casts, or another podcast app.
Apple Podcasts and Spotify do not show images in the episode description. Try Pocket Casts, or another podcast app.
351 tập
Tất cả các tập
×Chào mừng bạn đến với Player FM!
Player FM đang quét trang web để tìm các podcast chất lượng cao cho bạn thưởng thức ngay bây giờ. Đây là ứng dụng podcast tốt nhất và hoạt động trên Android, iPhone và web. Đăng ký để đồng bộ các theo dõi trên tất cả thiết bị.