Visualizing Membrane Dynamics by Electron Microscopy

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Explore how the latest electron microscopy techniques and volume imaging can capture fast, dynamic membrane and vesicle remodeling events during synaptic transmission at the ultrastructural level.

Neurons communicate at specialized junctions, or synapses, via chemical messengers called neurotransmitters. Within a millisecond of neuronal stimulation, synaptic vesicles packed with neurotransmitters fuse with the presynaptic plasma membrane and release their contents. These neurotransmitters then bind and activate receptors on the postsynaptic membrane, resulting in cell-to-cell signal transmission. Then, to sustain this neurotransmission, new vesicles are recruited to the release sites.

In this episode of Listen In, we dive into the powerful new technology to spatially and temporally investigate these dynamics.

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