))
Accelerating Antibiotic Discovery Using AI - On Tech Ethics
Manage episode 410254926 series 3440731
Nội dung được cung cấp bởi CITI Program. Tất cả nội dung podcast bao gồm các tập, đồ họa và mô tả podcast đều được CITI Program hoặc đối tác nền tảng podcast của họ tải lên và cung cấp trực tiếp. Nếu bạn cho rằng ai đó đang sử dụng tác phẩm có bản quyền của bạn mà không có sự cho phép của bạn, bạn có thể làm theo quy trình được nêu ở đây https://vi.player.fm/legal.
Discusses the use of artificial intelligence (AI) to accelerate antibiotic discovery.
Our guest today is César de la Fuente who is a Presidential Assistant Professor at the University of Pennsylvania. César’s research focuses on using computational approaches to accelerate discoveries in biology and medicine. Specifically, he pioneered the development of the first computer-designed antibiotic with efficacy in animal models, demonstrating the application of AI for antibiotic discovery and helping launch this emerging field.
Related publications:
- Pioneering study describing an antibiotic designed by AI with efficacy in preclinical mouse models: https://www.nature.com/articles/s41467-018-03746-3
- First exploration of the human proteome as a source of antibiotics, yielding numerous preclinical candidates: https://www.nature.com/articles/s41551-021-00801-1
- First therapeutic molecules (i.e., antibiotics) identified in extinct organisms, launching the field of molecular de-extinction: https://www.cell.com/cell-host-microbe/pdfExtended/S1931-3128(23)00296-2
- Relevant review in Science with the Collins Lab covering this emerging field: https://www.science.org/doi/10.1126/science.adh1114
Related media coverage:
- STAT - “Giant sloths and woolly mammoths: Mining past creatures’ DNA for future antibiotics:” https://www.statnews.com/2023/10/25/antibiotics-resistance-ancient-dna-cesar-de-la-fuente/
- Vox - “Using AI, scientists bring Neanderthal antibiotics back from extinction:” https://www.vox.com/future-perfect/23811682/ai-neanderthal-antibiotics-extinction
- CNN - “Why ‘resurrection biology’ is gaining traction around the world:” https://www.cnn.com/2023/12/26/world/resurrection-biology-extinct-species-virus-scn/index.html
Additional resources:
- De La Fuente Lab: http://delafuentelab.seas.upenn.edu/
- LinkedIn: https://www.linkedin.com/in/cesardelafuentenunez/
- X: https://twitter.com/delafuenteupenn
- CITI Program’s Bioethics course: https://about.citiprogram.org/course/bioethics/
- CITI Program’s Technology, Ethics, and Regulations course: https://about.citiprogram.org/course/technology-ethics-and-regulations/
31 tập
Chia sẻ
