Chuyển sang chế độ ngoại tuyến với ứng dụng Player FM !
#58 B cell maturation and class switching with Hamish King
Manage episode 288818441 series 1537951
In this episode, we learn about B cell maturation and class switching from Hamish King. Hamish recently published a paper on this subject in Science Immunology, where he and his coauthors analyzed gene expression and antibody repertoire data from human tonsils. In the episode Hamish talks about some of the interesting B cell states he uncovered and shares his thoughts on questions such as «When does a B cell decide to class-switch?» and «Why is the antibody isotype correlated with its affinity?»
Links:
- Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics (Hamish W. King, Nara Orban, John C. Riches, Andrew J. Clear, Gary Warnes, Sarah A. Teichmann, Louisa K. James) (paywalled by Science Immunology)
- Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturation (the preprint of the above Science Immunology paper)
- www.tonsilimmune.org: An immune cell atlas of the human tonsil and B cell maturation
If you enjoyed this episode, please consider supporting the podcast on Patreon.
70 tập
Manage episode 288818441 series 1537951
In this episode, we learn about B cell maturation and class switching from Hamish King. Hamish recently published a paper on this subject in Science Immunology, where he and his coauthors analyzed gene expression and antibody repertoire data from human tonsils. In the episode Hamish talks about some of the interesting B cell states he uncovered and shares his thoughts on questions such as «When does a B cell decide to class-switch?» and «Why is the antibody isotype correlated with its affinity?»
Links:
- Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics (Hamish W. King, Nara Orban, John C. Riches, Andrew J. Clear, Gary Warnes, Sarah A. Teichmann, Louisa K. James) (paywalled by Science Immunology)
- Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturation (the preprint of the above Science Immunology paper)
- www.tonsilimmune.org: An immune cell atlas of the human tonsil and B cell maturation
If you enjoyed this episode, please consider supporting the podcast on Patreon.
70 tập
모든 에피소드
×Chào mừng bạn đến với Player FM!
Player FM đang quét trang web để tìm các podcast chất lượng cao cho bạn thưởng thức ngay bây giờ. Đây là ứng dụng podcast tốt nhất và hoạt động trên Android, iPhone và web. Đăng ký để đồng bộ các theo dõi trên tất cả thiết bị.