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Nội dung được cung cấp bởi Dr. Kara Fitzgerald - Functional Med & Longevity and Dr. Kara Fitzgerald. Tất cả nội dung podcast bao gồm các tập, đồ họa và mô tả podcast đều được Dr. Kara Fitzgerald - Functional Med & Longevity and Dr. Kara Fitzgerald hoặc đối tác nền tảng podcast của họ tải lên và cung cấp trực tiếp. Nếu bạn cho rằng ai đó đang sử dụng tác phẩm có bản quyền của bạn mà không có sự cho phép của bạn, bạn có thể làm theo quy trình được nêu ở đây https://vi.player.fm/legal.
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Promise and Controversies: State of the State of Longevity Science with Matt Kaeberlein, PhD

1:25:09
 
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Manage episode 442112505 series 1149419
Nội dung được cung cấp bởi Dr. Kara Fitzgerald - Functional Med & Longevity and Dr. Kara Fitzgerald. Tất cả nội dung podcast bao gồm các tập, đồ họa và mô tả podcast đều được Dr. Kara Fitzgerald - Functional Med & Longevity and Dr. Kara Fitzgerald hoặc đối tác nền tảng podcast của họ tải lên và cung cấp trực tiếp. Nếu bạn cho rằng ai đó đang sử dụng tác phẩm có bản quyền của bạn mà không có sự cho phép của bạn, bạn có thể làm theo quy trình được nêu ở đây https://vi.player.fm/legal.
It's important to me to include a variety of voices in the sphere of aging and longevity, and Matt Kaeberlein PhD is certainly one that I appreciate for his tempered and rational arguments. I value his insights and his work with other scientists who are tussling with the challenging questions and research interpretations in this field. We are at this extraordinary inflexion point where scientists are debating the very definition of aging itself, which has important implications for how we then measure and study it. Dr. Kaeberlein shares his thoughts on this as well as the latest on longevity interventions such as rapamycin, metformin, intermittent fasting, and caloric restriction. Find out why he thinks we'll always hit a wall with moving the needle on lifespan, and why healthspan is such an important target. I think you will find this conversation illuminating and useful. An additional note for any of my listeners/readers who have been tracking the various discussions around the utility of epigenetic clocks and other measures of aging: I personally very much believe in epigenetics, even as the field continues to evolve. The foundation of this traces back to my beginnings in this field, working under my mentor Richard Lord PhD, who taught me that as scientists and clinicians we have no choice but to embrace uncertainty. No laboratory tests are as precise as many of us would like to think they are - microbiome, organic acid, nutrient testing, those foundational tools of functional medicine that we are very comfortable using, included. This applies to standard labs too - I recently received a notification from one of the two biggest labs in the US stating that, due to a change in the testing instrument used, values for red cell indices (the oldest tests on the planet!) would be altered compared to prior results. As clinicians we have to grapple with uncomfortable uncertainty in medicine every single day - from that reality we still have to move forward and make the best clinical decisions we can. Epigenetic age testing is simply another tool in the mix that can add value to understanding a patient's picture, and we can use it even as we interpret it with a similar acknowledgement of uncertainty. If you would like to add your thoughts to this discussion, please share below. - DrKF

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS

Matt Kaeberlein, PhD, CEO, Optispan https://tinyurl.com/2r89rvdd

Email Matt@optispan.life

THANKS TO OUR SPONSORS

DIAMOND

Integrative Therapeutics: https://tinyurl.com/4emwj48z

GOLD

TimeLine Nutrition: https://tinyurl.com/bdzx2xms

OneSkin: https://tinyurl.com/ycxtw4zt

MIDROLL

DUTCH: Learn more about DUTCH testing https://tinyurl.com/2y24st67

QUALIA: Try Qualia Senolytic with code KARA15 for 15% off at http://qualialife.com/Kara15

CONNECT WITH Dr. Fitzgerald on YouTube: https://tinyurl.com/hjpc8daz

  continue reading

184 tập

Artwork
iconChia sẻ
 
Manage episode 442112505 series 1149419
Nội dung được cung cấp bởi Dr. Kara Fitzgerald - Functional Med & Longevity and Dr. Kara Fitzgerald. Tất cả nội dung podcast bao gồm các tập, đồ họa và mô tả podcast đều được Dr. Kara Fitzgerald - Functional Med & Longevity and Dr. Kara Fitzgerald hoặc đối tác nền tảng podcast của họ tải lên và cung cấp trực tiếp. Nếu bạn cho rằng ai đó đang sử dụng tác phẩm có bản quyền của bạn mà không có sự cho phép của bạn, bạn có thể làm theo quy trình được nêu ở đây https://vi.player.fm/legal.
It's important to me to include a variety of voices in the sphere of aging and longevity, and Matt Kaeberlein PhD is certainly one that I appreciate for his tempered and rational arguments. I value his insights and his work with other scientists who are tussling with the challenging questions and research interpretations in this field. We are at this extraordinary inflexion point where scientists are debating the very definition of aging itself, which has important implications for how we then measure and study it. Dr. Kaeberlein shares his thoughts on this as well as the latest on longevity interventions such as rapamycin, metformin, intermittent fasting, and caloric restriction. Find out why he thinks we'll always hit a wall with moving the needle on lifespan, and why healthspan is such an important target. I think you will find this conversation illuminating and useful. An additional note for any of my listeners/readers who have been tracking the various discussions around the utility of epigenetic clocks and other measures of aging: I personally very much believe in epigenetics, even as the field continues to evolve. The foundation of this traces back to my beginnings in this field, working under my mentor Richard Lord PhD, who taught me that as scientists and clinicians we have no choice but to embrace uncertainty. No laboratory tests are as precise as many of us would like to think they are - microbiome, organic acid, nutrient testing, those foundational tools of functional medicine that we are very comfortable using, included. This applies to standard labs too - I recently received a notification from one of the two biggest labs in the US stating that, due to a change in the testing instrument used, values for red cell indices (the oldest tests on the planet!) would be altered compared to prior results. As clinicians we have to grapple with uncomfortable uncertainty in medicine every single day - from that reality we still have to move forward and make the best clinical decisions we can. Epigenetic age testing is simply another tool in the mix that can add value to understanding a patient's picture, and we can use it even as we interpret it with a similar acknowledgement of uncertainty. If you would like to add your thoughts to this discussion, please share below. - DrKF

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS

Matt Kaeberlein, PhD, CEO, Optispan https://tinyurl.com/2r89rvdd

Email Matt@optispan.life

THANKS TO OUR SPONSORS

DIAMOND

Integrative Therapeutics: https://tinyurl.com/4emwj48z

GOLD

TimeLine Nutrition: https://tinyurl.com/bdzx2xms

OneSkin: https://tinyurl.com/ycxtw4zt

MIDROLL

DUTCH: Learn more about DUTCH testing https://tinyurl.com/2y24st67

QUALIA: Try Qualia Senolytic with code KARA15 for 15% off at http://qualialife.com/Kara15

CONNECT WITH Dr. Fitzgerald on YouTube: https://tinyurl.com/hjpc8daz

  continue reading

184 tập

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