Can Cannabis Cancel Migraines?

ENCORE Research Group

Curious about cannabis and migraines? In this episode, we explore the intriguing connection between the two. Discover how cannabis, historically used for headache relief, is making a comeback in medical circles despite legal hurdles. We dive into the endocannabinoid system, THC, CBD, and their potential impacts on migraine pathways. Learn about the latest research, including a groundbreaking clinical trial published in Neurology, and what it reveals about cannabis as a treatment for migraine pain. Tune in to uncover the science, history, and future possibilities of using cannabis to combat migraines.
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References:
Leimuranta, P., Khiroug, L., & Giniatullin, R. (2018). Emerging role of (endo) cannabinoids in migraine. Frontiers in Pharmacology, 9, 420. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00420/full

Mechtler, L. L., Gengo, F. M., & Bargnes, V. H. (2021). Cannabis and migraine: it’s complicated. Current Pain and Headache Reports, 25, 1-13. https://link.springer.com/article/10.1007/s11916-020-00931-2

Rhyne, D. N., Anderson, S. L., Gedde, M., & Borgelt, L. M. (2016). Effects of medical marijuana on migraine headache frequency in an adult population. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 36(5), 505-510. https://accpjournals.onlinelibrary.wiley.com/doi/full/10.1002/phar.1673

Russo, E. (1998). Cannabisfor migraine treatment: the once and future prescription? An historical and scientific review. Pain, 76(1), 3-8. https://journals.lww.com/pain/abstract/1998/05000/cannabisfor_migraine_treatment__the_once_and.2.aspx

Russo, E. B. (2016). Clinical endocannabinoid deficiency reconsidered: current research supports the theory in migraine, fibromyalgia, irritable bowel, and other treatment-resistant syndromes. Cannabis and cannabinoid research, 1(1), 154-165. https://www.liebertpub.com/doi/full/10.1089/can.2016.0009

Schuster, N., Wallace, M., Buse, D., Marcotte, T., Lee, E., Liu, L., & Sexton, M. (2024, April). Vaporized Cannabis versus Placebo for Acute Migraine: A Randomized Controlled Trial (S22. 010). In Neurology (Vol. 102, No. 17_supplement_1, p. 3105). Hagerstown, MD: Lippincott Williams & Wilkins. https://www.neurology.org/doi/abs/10.1212/WNL.0000000000204925 (preprint available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10889030/)

Sexton, M., Cuttler, C., Finnell, J. S., & Mischley, L. K. (2016). A cross-sectional survey of medical cannabis users: patterns of use and perceived efficacy. Cannabis and cannabinoid research, 1(1), 131-138. https://www.liebertpub.com/doi/full/10.1089/can.2016.0007