Research Renaissance: Exploring The Future Of Brain Science podcast

Research Renaissance: Exploring the Future of Brain Science

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Nội dung được cung cấp bởi Karen Toffler Charitable Trust. Tất cả nội dung podcast bao gồm các tập, đồ họa và mô tả podcast đều được Karen Toffler Charitable Trust hoặc đối tác nền tảng podcast của họ tải lên và cung cấp trực tiếp. Nếu bạn cho rằng ai đó đang sử dụng tác phẩm có bản quyền của bạn mà không có sự cho phép của bạn, bạn có thể làm theo quy trình được nêu ở đây https://vi.player.fm/legal.

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Why Petra Needs Its People 28:39

cách đây 15 ngày trước28:39

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28:39

For centuries, members of the B’doul Bedouin tribe lived in the caves around the ancient city of Petra, Jordan. Then, in the 1980s, the government forced the tribe to move in the name of preserving the geological site for tourists. But if the residents are forced to leave, and if their heritage has been permanently changed, then what exactly is being preserved? SHOW NOTES: Meet The Man Living in The Lost City Carved in Stone Jordan: Petra's tourism authority cracks down on Bedouin cave dwellers The tribes paying the brutal price of conservation “There is no future for Umm Sayhoun” Jordan’s Young Bedouins Are Documenting Their Traditions on TikTok Check out Sami's company Jordan Inspiration Tours Learn about your ad choices: dovetail.prx.org/ad-choices…

Research Renaissance: Exploring the Future of Brain Science

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Delve into the frontiers of cutting-edge brain science with ‘Research Renaissance’ a podcast presented by the Karen Toffler Charitable Trust. Join us on a journey of discovery with a diverse lineup of guests, including early career researchers undertaking groundbreaking studies. Hear their insights alongside voices from investment communities, policymakers, and research institutions. Collectively we explore the complexities of neurological diseases, their root causes, potential treatments, and the pursuit of cures. Join us in illuminating the path towards a comprehensive understanding of the brain and advancements in addressing its ailments.

42 tập

#Science #Fitness #Biology #Medicine #News #Tech News #Karen Toffler Charitable Trust #Brain Science #Research Renaissance #Neuroscience #Groundbreaking Studies #Neurological Disease #Potential Treatments #Pursuit Of Cures #Early Career Researcher #Investment Communities #Policymakers #Advanced

Research Renaissance: Exploring the Future of Brain Science

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42 tập

Tất cả các tập

Research Renaissance: Exploring the Future of Brain Science

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Oxygen and Alzheimer’s: Dr. Nancy Ruiz on the Vascular Connection 41:02

cách đây 16 hours trước41:02

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Can oxygen levels in the brain help explain Alzheimer’s disease? In this episode of Research Renaissance , host Deborah Westfall sits down with Dr. Nancy Y. Ruiz, a Harvard Medical School research fellow and 2023 Toffler Scholar, to explore a powerful yet underexamined piece of the Alzheimer’s puzzle: vascular dysfunction. Dr. Ruiz shares how her background in physics and biology led her to cutting-edge brain research using advanced imaging tools like two-photon phosphorescence lifetime imaging. Together, they dive into how oxygenation, blood flow, and lifestyle factors such as exercise and diet may hold the key to prevention — and why we must look beyond amyloid and tau to fully understand the disease. Plus, hear Dr. Ruiz’s insights on the importance of interdisciplinary collaboration, working with human brain tissue, and how she balances scientific rigor with pottery, running, and a good meal. 📌 Don’t forget to follow and rate the show! New episodes explore the people, breakthroughs, and bold ideas shaping the future of brain science. To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org. Technical Podcast Support by Jon Keur at Wayfare Recording Co.…

Research Renaissance: Exploring the Future of Brain Science

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Innovation in Biotech & Leadership with Catharine Smith 55:20

cách đây 8 ngày trước55:20

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In this episode of Research Renaissance, host Deborah Westphal sits down with Catharine Smith, Executive Director of the Termeer Foundation, to explore innovation in the biotech industry and the evolving role of leadership. They dive into how biotech leaders are shaping the future of healthcare, supporting emerging companies, and addressing rare diseases. Key Topics Covered Catharine Smith’s Career Journey – From health services research to leading an influential foundation supporting biotech leaders. Biotech Leadership & Change Agents – What makes a great leader in the biotech space and how leadership is evolving. Henri Termeer’s Legacy – How the Termeer Foundation was founded and its impact on patient-centered biotech innovation. Supporting Biotech CEOs – Challenges, common needs, and how the foundation mentors and funds early-stage biotech leaders. Rare Disease & Patient Advocacy – The role of patient-driven biotech innovation and the partnerships making breakthroughs possible. Future of Biotech & Leadership – How AI, innovation, and a stronger emphasis on leadership will shape the next generation of biotech advancements. Memorable Quotes 🗣️ "The most effective biotech leaders are driven by an internal ‘why’—a passion for improving patient care and making an impact." – Catharine Smith 🗣️ "If we look at rare diseases as a collective, they’re not rare at all. The unmet need is massive, and we’re seeing patient advocates leading the way in finding solutions." – Catharine Smith Resources & Mentions Termeer Foundation: termeerfoundation.org Book Recommendation: Conscience and Courage – The story of Henri Termeer’s life and legacy. Rare Disease Advocacy: Learn more about patient-led biotech innovations and advocacy groups. Connect With Us 📌 Follow Research Renaissance: Website | LinkedIn 📌 Follow Catharine Smith & The Termeer Foundation: LinkedIn 💡 Enjoyed the episode? Subscribe, leave a review, and share it with colleagues interested in biotech innovation and leadership! 🔍 Want to learn more or collaborate? Contact Karen Toffler Charitable Trust via our website or LinkedIn 🎧 Listen & Subscribe: Available on Spotify, Apple Podcasts, and other major platforms. Until next time—onward and upward! 🚀 To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org. Technical Podcast Support by Jon Keur at Wayfare Recording Co.…

Research Renaissance: Exploring the Future of Brain Science

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Exploring the Future of Science Policy with Dr. Carrie Wolinetz 59:43

cách đây 14 ngày trước59:43

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In this episode of Research Renaissance , host Deborah Westphal welcomes Dr. Carrie Wolinetz, a leading science and health policy expert. With an extensive background, including roles at the National Institutes of Health (NIH) and the White House Office of Science and Technology Policy, Dr. Wolinetz shares her insights on the evolving landscape of medical research funding, the role of science policy, and the critical intersection between government, private sector, and research institutions. From the historical foundations of federally funded science to the challenges posed by shifting political landscapes, Dr. Wolinetz offers a compelling perspective on the future of research and public health. What You’ll Learn in This Episode 🔬 The Role of Science Policy: How policy shapes the research ecosystem and why it’s essential for medical advancements. 🧬 The Impact of Federally Funded Research: The return on investment from initiatives like the Human Genome Project and how they’ve revolutionized medicine. 🌎 The Changing Landscape of Research Funding: How federal funding priorities are shifting and what researchers need to prepare for. 💰 The Future of Public-Private Partnerships: How government, academia, and the private sector must collaborate to accelerate breakthroughs. ⚖️ The Debate on Indirect Costs (F&A Rates): Understanding the recent policy changes and their impact on research institutions. 📢 The Importance of Science Communication: Why researchers must engage in public discussions to build trust and transparency. 🧑‍🔬 Advice for Early-Career Researchers: How young scientists can navigate funding uncertainties and thrive in a rapidly evolving research environment. 💡 The Next Frontier in Public Health: What’s needed to create a robust and proactive health infrastructure for future global challenges. Key Quotes from Dr. Carrie Wolinetz 💭 “Science is all about solving problems. The best research happens when patients, researchers, and policymakers work together.” 💭 “The Human Genome Project had a 141-to-1 return on investment—nearly a trillion dollars in impact.” 💭 “Science isn’t just about discovery; it’s about making sure discoveries lead to real-world impact.” 💭 “We need a new national vision for public health—one that integrates the lessons of COVID-19 and prioritizes rapid response to emerging threats.” Resources & Links 📌 Karen Toffler Charitable Trust: tofflertrust.org 📌 Dr. Carrie Wolinetz on LinkedIn: LinkedIn Profile 📌 NIH Office of Science Policy: NIH Science Policy 📌 The 100-Day Mission for Pandemic Preparedness: Learn More Stay Connected 📢 Subscribe for More Episodes! Stay informed on groundbreaking research and policy discussions shaping the future of science. 🌐 Visit tofflertrust.org for updates and initiatives. 📩 Have thoughts or questions? Reach out to us—we’d love to hear from you! 🎧 Listen & Subscribe on Your Favorite Platform 📌 Apple Podcasts | Spotify | Google Podcasts | Stitcher | Amazon Music 🚀 Until next time—onward and upward! To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org. Technical Podcast Support by Jon Keur at Wayfare Recording Co.…

Research Renaissance: Exploring the Future of Brain Science

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Revolutionizing ALS Drug Development with Dr. Kasper Roet 46:48

cách đây 22 ngày trước46:48

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Welcome to Research Renaissance , presented by the Karen Toffler Charitable Trust. In this episode, host Deborah Westphal sits down with Dr. Kasper Roet, CEO and co-founder of QurAlis, to explore the evolution of ALS drug development, the power of genetic insights, and the future of personalized medicine for neurodegenerative diseases. 🔬 Episode Highlights: ✔️ From Spinal Cord Injury to ALS – Dr. Roet’s journey from spinal cord injury research to ALS, and how genetic discoveries reshaped his focus. ✔️ A New Era for Drug Development – The pivotal role of genomics, AI, and stem cell technology in accelerating ALS treatments. ✔️ Precision Medicine & Stem Cells – How patient-derived pluripotent stem cells are transforming ALS research. ✔️ Cure ALS: The Mission & Breakthroughs – The pioneering therapies Quralis is developing to target ALS at the molecular level. ✔️ Challenges in Biotech Entrepreneurship – The leap from scientist to CEO, raising funds, and the mentorship that helped shape his journey. ✔️ The Future of Neurological Disease Research – What’s next for genetic medicine, biomarkers, and targeted treatments? 💡 Key Takeaways: 🔹 ALS is no longer a “mystery disease” – recent genetic breakthroughs are leading to targeted treatments. 🔹 Traditional animal models are failing to replicate human disease—patient-derived stem cells are offering a more reliable solution. 🔹 The intersection of AI, big data, and molecular biology will drive the next wave of personalized medicine. 🔹 Biotech innovation demands a balance between scientific rigor and entrepreneurial agility. 🔹 The industry must shorten drug development timelines to bring life-saving treatments to patients faster. 🎧 Listen Now & Subscribe! Stay ahead in the world of cutting-edge neuroscience and biotech breakthroughs. Subscribe to Research Renaissance on your favorite podcast platform and visit TofflerTrust.org for more insights. 🔗 Want to collaborate or learn more? Connect with Dr. Kasper Roet and his team at Quralis or email info@quralis.com. 🚀 Join us in advancing the future of brain research—because patients can’t wait! To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org. Technical Podcast Support by Jon Keur at Wayfare Recording Co.…

Research Renaissance: Exploring the Future of Brain Science

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The Future of Research & Development with Dr. Melissa Flagg 1:05:39

cách đây 29 ngày trước1:05:39

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In this thought-provoking episode of Research Renaissance , host Deborah Westphal welcomes Dr. Melissa Flagg, an advisor for the Andrew W. Marshall Foundation and a research fellow at the Acquisition Innovation Research Center. Dr. Flagg has had an extensive career spanning government, academia, and the private sector, including her role as Deputy Assistant Secretary of Defense for Research. Together, they explore the evolving landscape of research and development (R&D) in the U.S. and beyond. They discuss the history, funding models, and gaps in the system, as well as new opportunities to connect scientific research with real-world applications. Dr. Flagg also offers a candid perspective on how research institutions prioritize funding, the challenges faced by early-career researchers, and the growing influence of industry and philanthropy in driving scientific innovation. 💡 Key Topics Discussed: ✅ The complexity of the U.S. research ecosystem and how it has evolved since WWII ✅ The shift from federal government dominance in R&D to industry-driven funding ✅ The gap between academic research and real-world solutions—why so many discoveries remain unused ✅ The replication crisis and the challenges of publishing scientific research ✅ How patient advocacy groups and regional initiatives can reshape research funding ✅ Why the U.S. needs new funding models to prioritize impact over publications ✅ The need for better compensation for researchers to improve the quality of scientific output ✅ Why philanthropy and communities should play a larger role in directing research efforts 📢 Memorable Quotes from Dr. Melissa Flagg: 🗣️ “We need to stop prioritizing scale and proxy measures of success like publications and focus on real impact.” 🗣️ “Basic research is critical, but without application pathways, it won’t help anyone.” 🗣️ “If we want high-quality research, we need to pay scientists what they’re worth.” 🗣️ “There’s no single list of everyone who might be interested in what you’re doing—you have to actively find your people.” 🎧 Tune in to hear a powerful conversation on the past, present, and future of research! 🔗 Connect with Dr. Melissa Flagg: Website: www.flaggconsulting.com LinkedIn: Melissa Flagg 📍 Learn More: Visit the Karen Toffler Charitable Trust for more insights into neurological research and innovation: www.tofflertrust.org 💡 Join the Conversation: Have thoughts or ideas? Subscribe, leave a review, and let us know what topics you’d love to hear next! 🎙️ Listen Now! 🚀 To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org. Technical Podcast Support by Jon Keur at Wayfare Recording Co.…

Research Renaissance: Exploring the Future of Brain Science

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Reversing Cognitive Decline: The Power of Lifestyle Medicine with Dr. Dean Ornish 35:35

cách đây 5 weeks trước35:35

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In this enlightening episode of Research Renaissance , host Deborah Westphal sits down with Dr. Dean Ornish, founder of the Preventative Medicine Research Institute and a pioneer in lifestyle medicine. Dr. Ornish shares groundbreaking research on how lifestyle changes—including diet, exercise, stress management, and social connection—can not only prevent but even reverse chronic diseases, including early-stage Alzheimer’s disease. With nearly five decades of research, Dr. Ornish discusses how a whole-food, plant-based diet, moderate exercise, mindfulness practices, and social support can lead to remarkable improvements in cognition, heart disease, cancer, and even gene expression. This episode dives deep into the science behind these findings, the pushback from traditional medicine, and the potential for insurance coverage of preventive healthcare. Join us for a conversation that challenges conventional medical thinking and offers hope and empowerment for those at risk of cognitive decline and other chronic conditions. Key Topics Discussed: ✔️ What is Lifestyle Medicine? – How simple lifestyle changes can be more effective than high-tech, expensive treatments. ✔️ Reversing Heart Disease & Alzheimer's – The research-backed approach to stopping and even reversing disease progression. ✔️ The Science of Longevity – How lifestyle changes can lengthen telomeres and improve overall health at a cellular level. ✔️ Pushback from Traditional Medicine – Why it took decades for these ideas to gain traction in the medical community. ✔️ Medicare & Insurance Coverage – How lifestyle medicine is becoming more accessible through insurance programs. ✔️ The Role of Social Connection – Why love and support are just as crucial as diet and exercise in health and longevity. ✔️ Technology, Stress & Aging – The impact of digital overload and how mindfulness practices can counteract modern stressors. Quotable Moments: 🗣️ "It’s not about fear of dying—it’s about the joy of living." – Dr. Dean Ornish 🗣️ "Your genes are not your fate. Lifestyle changes can turn on protective genes and turn off disease-promoting ones." 🗣️ "What’s good for your heart is good for your brain." Resources & Links: 🔗 Learn more about Dr. Ornish’s work: Ornish.com 🔗 Research & Studies: Preventive Medicine Research Institute (PMRI) 🔗 Dr. Ornish’s Book: Undo It! (co-authored with Anne Ornish) 📢 Stay Connected: 🔔 Subscribe for more episodes of Research Renaissance 🌐 Visit: TofflerTrust.org 📩 Got thoughts or questions? Reach out to the Karen Toffler Charitable Trust 🎧 Listen Now & Discover How Lifestyle Medicine is Changing the Future of Health! To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org. Technical Podcast Support by Jon Keur at Wayfare Recording Co.…

Research Renaissance: Exploring the Future of Brain Science

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The Future of Alzheimer's Treatment: Philanthropy, Innovation, and Hope with Katie Pizzone 44:52

cách đây 6 weeks trước44:52

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In this episode of Research Renaissance , host Deborah Westphal speaks with Katie Pizzone, Senior Director of Philanthropy at the Alzheimer’s Drug Discovery Foundation (ADDF). They discuss the critical role of philanthropy in advancing Alzheimer's research, the groundbreaking venture philanthropy model that ADDF employs, and the innovative treatments and diagnostics shaping the future of Alzheimer’s care. Katie shares her personal journey into philanthropy, her early experiences in healthcare fundraising, and how ADDF is working to accelerate translational science—bringing new diagnostics, treatments, and preventive solutions from research to real-world impact. Join us for a thought-provoking conversation about the intersection of philanthropy and science, the growing field of precision medicine, and how collaboration is key to curing Alzheimer’s. Key Topics Discussed: ✔️ The Power of Venture Philanthropy – How ADDF’s unique funding model bridges the gap between early research and real-world treatments. ✔️ From Research to Patient Impact – The challenges and breakthroughs in getting Alzheimer’s treatments to market. ✔️ New Frontiers in Alzheimer’s Science – The role of repurposed drugs, biomarkers, and combination therapies in future treatments. ✔️ The Importance of Early Diagnosis – Why diagnostics are critical for prevention and personalized medicine. ✔️ Diversity in Clinical Trials – Addressing the disparities in Alzheimer’s research and treatment development. ✔️ The Role of Relationships in Philanthropy – Why trust, collaboration, and long-term partnerships drive innovation. ✔️ The Future of Neurological Research – How AI, imaging, and other technological advancements are accelerating breakthroughs. Quotable Moments: 🗣️ "100% of every donation goes directly to science, thanks to a transformative gift from the Lauder family." – Katie Pizzone 🗣️ "Philanthropy isn’t just about funding—it’s about relationships, trust, and championing the mission together." 🗣️ "The future of Alzheimer’s treatment is precision medicine, combination therapies, and prevention—just like in cancer." Resources & Links: 🔗 Learn more about Alzheimer’s Drug Discovery Foundation: ALZdiscovery.org 📩 Contact Katie Pizzone: kpizzone@alzdiscovery.org 📚 Explore the latest in Alzheimer’s research funding and opportunities. 📢 Stay Connected: 🔔 Subscribe for more episodes of Research Renaissance 🌐 Visit: TofflerTrust.org 📩 Join the conversation and explore funding opportunities in brain science research! 🎧 Listen Now & Discover How Philanthropy is Driving Breakthroughs in Alzheimer’s Treatment! To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org. Technical Podcast Support by Jon Keur at Wayfare Recording Co.…

Research Renaissance: Exploring the Future of Brain Science

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Exploring Cognitive Super Aging and Brain Science with Dr. Tamar Gefen 53:41

cách đây 23 weeks trước53:41

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In this episode of Research Renaissance, host Deborah Westphal sits down with Dr. Tamar Gefen, an Associate Professor at the Mesulam Center for Cognitive Neurology and Alzheimer’s Disease at Northwestern University. Dr. Gefen, a 2023 Toffler Scholar, shares insights into her groundbreaking work on dementia syndromes and age-related cognitive disorders, including her fascinating research on cognitive "super agers." Key Discussion Points: Dr. Gefen’s personal journey to becoming a clinical neuropsychologist and her passion for studying the human brain. What it means to be a neuropsychologist and how it combines the study of brain structure with behavior and function. An exploration of cognitive super agers: individuals over 80 whose memory functions as if they were decades younger. The significance of brain donation in Dr. Gefen’s research, as well as the emotional and spiritual connection she feels to the work. Insights into her research lab’s ongoing studies and how it’s contributing to the field of neurology and cognitive health. The importance of identifying modifiable risk factors for dementia, and how individuals can reduce their risk by focusing on heart and brain health. Key Quotes: "I feel like I’m among tiny gods lined up in a fridge... These organs were the source of life for every human that made that precious donation." – Dr. Tamar Gefen "Aging suffers from poor marketing, and we need to show that aging can be graceful and fun." – Dr. Tamar Geffen Thank you for joining us on this insightful journey into brain science. Be sure to subscribe to Research Renaissance for more conversations at the cutting edge of neurological research. Until next time, onward and upward! To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org. Technical Podcast Support by Jon Keur at Wayfare Recording Co.…

Research Renaissance: Exploring the Future of Brain Science

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Empowering Future Scientists: The SARE Program at Johns Hopkins University 52:35

cách đây 24 weeks trước52:35

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Guests: Dr. Doug Robinson – Director of the Initiative for Careers in Science and Medicine, Johns Hopkins University Pamela Hamm – Director of the Summer Academic Research Experience (SARE) Eleana Parajon – Graduate Student and former SARE Scholar Temitope Adenaike – Current SARE Scholar Aiden Houser – Current SARE Scholar Summary: In this episode, we dive into the transformative Summer Academic Research Experience (SARE) at Johns Hopkins University, a program designed to provide high school students from underrepresented communities the opportunity to gain hands-on research experience. Dr. Doug Robinson and Pamela Hamm share the program’s vision, while current students and alumni, including Eleana, Temi and Aiden, recount their personal journeys in research and mentorship. We explore the program’s long-term impact, its unique structure, and the challenges in scaling it to reach even more young scientists. Key Topics: The SARE program's unique combination of academic instruction and real-world research experience Stories from SARE scholars on how the program has shaped their educational and career aspirations The critical role of mentorship in empowering the next generation of scientists Insights on the long-term success of SARE, with 74% of participants graduating college within four years Challenges in sustaining and expanding the program, including funding and lab space limitations The future vision for SARE to grow beyond Johns Hopkins and expand across the country Memorable Quotes: "We want to see scholars who are inspired, motivated, and fired up. This program is about giving them the opportunity to realize their full potential." – Dr. Doug Robinson "When students spend eight weeks feeling valued, listened to, and seen, it motivates them to go back into their schools and ask for what they need. It’s incredible to watch their growth." – Pamela Hamm "The SARE program made me love science even more. It gave me the confidence to know that I can pursue this as a career." – Temitope Adenaike, SARE Scholar “I was just really proud of the fact that now large organizations like QuestBridge are recognizing my potential, talent and ability.” - Aiden Houser, SARE Scholar "I hope for a more equitable health landscape. Investing in young people is the key to making that a reality." – Eleana Parajon, SARE Graduate and Mentor To learn more about the SARE program and how to support its mission, visit the Initiative for Careers in Science and Medicine (CSM) at Johns Hopkins here . For partnership opportunities or to contribute to the program, contact Dr. Doug Robinson at dnr@jhi.edu. Applications for the 2025 SARE program open on November 1st and close on February 1st. Visit the SARE program page for details on how to apply. Thank you for joining us on this episode of Research Renaissance . Stay tuned for more discussions with leading voices in brain science and the people shaping the future of research. Until next time—onward and upward! To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org. Technical Podcast Support by Jon Keur at Wayfare Recording Co.…

Research Renaissance: Exploring the Future of Brain Science

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Exploring the Future of Alzheimer's Research with Dr. Robert Vassar 57:26

cách đây 26 weeks trước57:26

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In this enlightening episode of Research Renaissance, Deborah Westphal speaks with Dr. Robert Vassar, a renowned neuroscientist and Director of the Mesulam Center for Cognitive Neurology and Alzheimer's Disease at Northwestern University. Dr. Vassar shares his personal journey into the field of Alzheimer’s research, the evolution of diagnostic tools, and the latest technological breakthroughs in the fight against neurodegenerative diseases. Key Topics Covered: Dr. Vassar’s Early Inspirations: Dr. Vassar shares his childhood fascination with science, the path that led him away from his dream of becoming an astronaut, and his ultimate decision to pursue biology and neuroscience. The Influence of Family: A deeply personal connection to Alzheimer’s, driven by his mother’s diagnosis in 1983, crystallized Dr. Vassar’s purpose and career focus on researching this devastating disease. Advances in Alzheimer’s Diagnosis: Dr. Vassar details how the process of diagnosing Alzheimer’s has transformed from rudimentary memory tests in the 1980s to advanced tools like positron emission tomography (PET) scans and emerging blood biomarker technologies. The Role of Transgenic Mice in Alzheimer’s Research: Dr. Vassar explains the development of Alzheimer’s disease transgenic mice and their critical role in understanding the disease’s pathology and developing new treatments. Mentorship and Scientific Thinking: Insights from his postdoctoral experience with Nobel Laureate Richard Axel taught Dr. Vassar methodical scientific thinking, a key lesson he now passes on to his mentees. Exciting New Therapies on the Horizon: The potential of anti-tau therapies, antisense oligonucleotides (ASOs), and microglial cell research as promising avenues in Alzheimer’s treatment are explored. Super-Aging Research: Dr. Vassar discusses Northwestern’s unique research on “superagers,” elderly individuals with superior cognitive function, and the factors that may contribute to their resilience against dementia. The Importance of Multidisciplinary Approaches: From molecular studies to societal impacts, Dr. Vassar emphasizes the value of combining pharmacological and non-pharmacological methods in understanding and treating Alzheimer’s disease. Memorable Quotes: "My purpose in life crystallized when my mother was diagnosed with Alzheimer's. I knew I had to study this disease to try to stop it." "The future of Alzheimer’s treatment will rely on prevention. We need to catch the disease before symptoms even begin." "Our study participants are the real heroes. Without their altruistic contributions, we couldn’t make any progress." Listeners interested in supporting Alzheimer’s research or participating in studies at Northwestern can visit the Mesulam Center for Cognitive Neurology and Alzheimer's Disease website for more information. The center welcomes volunteers for clinical trials and other research initiatives. For more updates on cutting-edge research in brain science, subscribe to Research Renaissance and visit the Karen Toffler Charitable Trust website at tofflertrust.org . Share your thoughts, suggestions, or inquiries by contacting us through the website. To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org. Technical Podcast Support by Jon Keur at Wayfare Recording Co.…

Research Renaissance: Exploring the Future of Brain Science

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Pioneering Drug Delivery for Neurological Diseases with Afreen Allam 46:30

cách đây 27 weeks trước46:30

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In this compelling episode of Research Renaissance , host Deborah Westphal sits down with Afreen Allam, the CEO and founder of SiNON Nano Sciences and a 2023 Termeer Fellow. Afreen shares her journey from aspiring medical student to biotech entrepreneur, discussing her groundbreaking work in drug delivery for neurological diseases. The conversation delves into the challenges and triumphs of developing a platform that can cross the blood-brain barrier, offering hope for the treatment of diseases like Cancer, Alzheimer's, Parkinson's, and brain tumors. Key Discussion Points: SiNON Nano Sciences' Mission: Afreen explains the innovative approach her company takes to target drug delivery across the blood-brain barrier, using a carbon-based nanoparticle that can safely and effectively transport medications to the brain. Personal Journey: Afreen reflects on her transition from a pre-medical student to a biotech entrepreneur, sharing how her experiences volunteering at the Duke Cancer Center inspired her to pursue research that could improve the quality of life for patients. Challenges in Drug Delivery: The discussion covers the unique difficulties of delivering drugs to the brain, the limitations of current technologies, and how SiNON Nano Sciences aims to overcome these obstacles with their platform. The Importance of Support and Mentorship: Afreen highlights the significance of mentorship and support systems, particularly her experience as a 2023 Termeer Fellow, which provided her with valuable resources, connections, and guidance. The Future of Drug Delivery: Afreen discusses the potential partnerships with pharmaceutical companies and the importance of collaboration in advancing treatments for neurological diseases. Guest Bio: Afreen Allam is the CEO and founder of SiNON Nano Sciences, a biotech startup focused on developing a platform for targeted drug delivery to the brain. A 2023 Termeer Fellow, Afreen is passionate about improving patient outcomes and has a background in biochemistry, microbiology, and business. Call to Action: Subscribe to Research Renaissance for more episodes featuring trailblazers in brain science and healthcare innovation. Visit tofflertrust.org for additional resources and updates. Until then, onward and upward! To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org. Technical Podcast Support by Jon Keur at Wayfare Recording Co.…

Research Renaissance: Exploring the Future of Brain Science

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Unraveling the Senses: Dr. Douglas Storace on the Olfactory Bulb and Brain Function 1:00:59

cách đây 28 weeks trước1:00:59

1:00:59

Welcome to the latest episode of Research Renaissance, presented by the Karen Toffler Charitable Trust. I’m your host, Deborah Westphal, and today, we have the pleasure of speaking with Dr. Douglas Storace, a neuroscientist and assistant professor at Florida State University. Dr. Storace is also a 2022 Toffler Scholar. Our discussion will delve into his research on the olfactory bulb, a crucial brain region responsible for processing smells, and its broader implications for understanding brain function and our bodies. Episode Highlights Dr. Storace's Journey to Neuroscience: Discover how a course on Sensation and Perception, combined with an interest in computers and music, led Dr. Storace to pursue a career in neuroscience. Understanding the Olfactory Bulb: Learn about the olfactory bulb's role as the brain's initial point of contact for sensory information from the nose and how it interacts with other brain regions. The Hypothalamus Connection: Dr. Storace shares fascinating insights into how the hypothalamus, a brain area involved in key behavioral functions, influences the olfactory bulb. Neuropeptides and Brain Function: Explore the role of the neuropeptide orexin in regulating sleep, feeding, and other behaviors, and its connection to the olfactory bulb. Current Lab Projects: An overview of Dr. Storace’s lab projects, including research on sensory information processing, perceptual stability, and a unique study involving blind cavefish to understand sensory adaptation. Technological Advances in Neuroscience: Discover the cutting-edge imaging techniques and fluorescent proteins that enable scientists to study the brain in unprecedented detail. Future Directions: Dr. Storace shares his hopes for future breakthroughs in neuroscience, particularly in understanding brain function and developing targeted treatments for neurological disorders. Thank you for joining us on this episode of Research Renaissance. For more information and to stay updated on our latest episodes, subscribe to the podcast and visit our website at tofflertrust.org . Feel free to contact us with your thoughts, suggestions, or to learn more about the Karen Toffler Charitable Trust. Until we meet again, onward and upward! To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org. Technical Podcast Support by Jon Keur at Wayfare Recording Co.…

Research Renaissance: Exploring the Future of Brain Science

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The Power of Strategic Communication in Healthcare with Anne Woodbury 54:51

cách đây 29 weeks trước54:51

54:51

In this episode of Research Renaissance , host Deborah Westphal sits down with Anne Woodbury, the founder and CEO of Cura Strategies, a healthcare communication and public affairs agency. Together, they explore the crucial role of strategic communication in shaping healthcare policies and improving patient outcomes. Anne shares her journey from Capitol Hill to entrepreneurship, driven by a passion for transforming the healthcare system. Listeners will gain insights into how effective advocacy and communication strategies can drive change in healthcare, the importance of educating policymakers, and the growing awareness around mental health in the corporate world. Anne also discusses Cura Cares, her company's charitable arm, and its impact on both employees and the communities they serve. Key Discussion Points: Anne’s Journey to Founding Cura Strategies: From her early days working with a member of Congress to leading a successful public affairs agency focused on healthcare. The Nexus of Policy and Strategic Communication: How Cura Strategies bridges the gap between healthcare communication and policy-making to advance quality and access in healthcare. The Role of Advocacy in Healthcare: Understanding the importance of educating policymakers and the general public about healthcare issues. Mental Health Advocacy: How Cura Strategies prioritizes mental health within the workplace and the broader impact of their advocacy work on public health policies. Cura Cares Program: A look at Cura Strategies’ charitable initiatives aimed at staying connected to community needs and improving public health. The Challenge of Trust in Healthcare: Discussing the trust deficit between the public, government, and healthcare institutions and what can be done to rebuild it. For more information about Cura Strategies and their work in healthcare communication and advocacy, visit CuraStrategies.com or AdvocacyAccelerator.us . You can also connect with Anne Woodbury on LinkedIn. Don't forget to subscribe to Research Renaissance for more insightful episodes exploring the forefront of brain science and healthcare innovation. Visit TofflerTrust.org for additional resources and updates. Until then, onward and upward! To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org. Technical Podcast Support by Jon Keur at Wayfare Recording Co.…

Research Renaissance: Exploring the Future of Brain Science

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Unraveling ALS and Genetic Modifiers with Dr. Zhe Zhang 46:55

cách đây 30 weeks trước46:55

46:55

In this insightful episode of Research Renaissance, host Deborah Westphal engages in an enlightening conversation with Dr. Zhe Zhang, a research associate at Johns Hopkins and a 2021 Toffler Scholar. Dr. Zhang discusses her journey from aspiring to be a doctor to becoming a dedicated researcher focused on neurodegenerative diseases, particularly ALS. She shares her innovative work on establishing a platform to find genetic modifiers that can improve cell survival and slow the progression of ALS. Key Discussion Points: Introduction to Dr. Zhe Zhang: Background and inspiration for pursuing research in neurodegenerative diseases. Transition from clinical practice to basic research. Journey to ALS Research: Initial interest sparked by experiences with neurodegenerative patients during medical training. Shift in focus during her time in Australia, influenced by collaborations and the Ice Bucket Challenge. Focus on Genetic Modifiers and ALS: Explanation of familial and sporadic ALS, with a focus on the C9ORF72 gene mutation. Development of toxic proteins from gene mutations and their impact on cell survival. Research Techniques and Platforms: Use of CRISPR technology for genetic screening and identifying potential therapeutic targets. Application of human induced pluripotent stem cells (iPSCs) to develop models for screening. Collaborative Efforts: Importance of interdisciplinary collaborations with other researchers and biobanks. Contributions from patient-donated post-mortem tissues to validate research findings. Challenges and Future Directions: The complexity of translating basic research to clinical applications and commercial products. The role of CRISPR in gene editing and its potential for therapeutic interventions. Emerging Technologies and Tools: The impact of iPSCs, CRISPR, and advanced imaging techniques on ALS research. Potential of functional MRI and other non-invasive methods for tracking disease progression. Global Collaboration and Impact: The necessity of global studies and collaborations to understand neurodegenerative diseases. Hopes for future research, including the development of effective therapies for ALS. Personal Reflections and Advice: Dr. Zhang’s commitment to staying curious, passionate, and cautious in her research. Encouragement for young researchers to persevere despite challenges and to collaborate widely. Join us in advancing our understanding of the brain and addressing its ailments. Until then, onward and upward! To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org. Technical Podcast Support by Jon Keur at Wayfare Recording Co.…

Research Renaissance: Exploring the Future of Brain Science

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Neurovascular Breakthroughs: Exploring Alzheimer's Treatments with Dr. Elisa Canepa 47:50

cách đây 31 weeks trước47:50

47:50

In this enlightening episode of Research Renaissance, host Deborah Westphal engages in a compelling conversation with Dr. Elisa Canepa, a neurobiologist and associate scientist from Temple University and a 2022 Toffler Scholar. Dr. Canepa shares her journey into neuroscience, driven by a fascination with the brain's complexity and its pivotal role in shaping our identity and cognitive functions. They delve into Dr. Canepa’s cutting-edge research on cerebral vascular dysfunction, particularly focusing on the potential of carbonic anhydrase inhibitors (CAIs) in treating Alzheimer's disease. Key Discussion Points: Introduction to Dr. Elisa Canepa: Background and inspiration for pursuing neuroscience. Current role at Temple University and involvement with the Karen Toffler Charitable Trust. Research Focus: Investigation into the role of carbonic anhydrase inhibitors in Alzheimer's treatment. Mechanisms behind CAIs’ ability to rescue cognitive functions and ameliorate neurovascular dysfunction. Recent findings published in the Alzheimer's and Dementia Journal. Experimental Techniques: Behavioral tasks to measure cognitive impairment and the effectiveness of treatments in animal models. Advanced techniques like RNA sequencing and RNA scope to study the molecular changes in the brain. Impact of High Altitude Physiology: Exploration of the physiological differences in people living at high altitudes and potential insights for Alzheimer's research. Future Directions and Challenges: Potential clinical applications and the pathway to clinical trials for CAIs. The importance of interdisciplinary collaborations and combining different expertise to advance research. The role of biomarkers and advanced imaging techniques in predicting and diagnosing neurological diseases. Personal and Professional Insights: Dr. Canepa’s reflections on the importance of raising awareness about Alzheimer's disease. The significance of combining basic science research with outreach and advocacy efforts. The global nature of neurodegenerative research and collaborations across countries. Emerging Research Areas: Investigations into tauopathies and their impact on vascular health. The intersection of cardiovascular health and Alzheimer's disease, particularly in the context of Western diets and lifestyle factors. Join us in advancing our understanding of the brain and addressing its ailments. Until then, onward and upward! To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org. Technical Podcast Support by Jon Keur at Wayfare Recording Co.…

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