The Black Death and Autoimmunity

Healio Rheuminations

Was your psoriasis caused by the Black Death? Learn more than you might have wanted to know about the Black Death and delve into the data on the immunologic/autoimmune ramifications of wiping out nearly half of Europe.

· Intro 0:11

· In this episode 1:09

· The Black Death 1:24

· The History of IV Immunoglobulin episode 2:07

· How the Black Death happened 4:07

· How many people died from the Black Death? 6:49

· Record keeping 6:53

· The modern immune system, the Black Death and HIV 8:43

· What is CCR5? 8:55

· Current data on autoimmune diseases 10:35

· ERAP2 15:55

· How yersinia pestis kills you 21:04

· The inflammasome 22:03

· The Inflammasome for Dunces episode 22:09

· Mediterranean fever and mouse model 24:49

· Takeaways 30:20

· Summary 30:59

Disclosures: Brown reports no relevant financial disclosures.

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References:

Wheelis M. Emerg Infect Dis. 2002;doi:10.3201/eid0809.100536.

Ratner D, et al. PLoS Pathog. 2016;doi:10.1371/journal.ppat.1006035.

Park YH, et al. Nat Immunol. 2020;doi:10.1038/s41590-020-0705-6.

Patin E. Nat Immunol. 2020;doi:10.1038/s41590-020-0724-3.

Galvani AP, et al. Proc Natl Acad Sci USA. 2003;doi:10.1073/pnas.2435085100.