Peanut Protein Causes Cancer To Metastasize?

The Alpha Human Podcast

Disclaimer: The content of this podcast, and any information, advice, opinions or statements within it are not intended, and are not to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not disregard or delay in obtaining medical advice for any medical condition you may have, and you should seek the assistance of a healthcare professional for any such conditions, and always inform your doctor of any changes you make, or are thinking about making to your lifestyle. In this episode of the Alpha Human Podcast, Lawrence Rosenberg discusses the potential link between the consumption of peanuts and cancer metastasis. Peanuts contain peanut agglutinin (PNA), a lectin that binds to a complex sugar known as the T-antigen, a glycan bound to proteins found on certain cancer cells. This interaction mimics the actions of galectin-3, an endogenously produced human lectin (often overexpressed in cancer patients) that can bind to dysregulated glycoproteins on the membranes of cancer cells leading to enhanced cellular adhesion, invasion, migration, metastasis, angiogenesis, and immune evasion. Additionally, PNA has been shown to interact with endothelial cells and trigger the secretion of metastasis-promoting cytokines that can lead to increased adhesion between tumor cells and blood vessel walls, facilitating tumor cell metastasis. Lawrence also highlights modified citrus pectin (mCP), a natural compound that has been found to block galectin-3 activity and inhibit tumor growth. Additionally, mCP has shown promising results targeting multiple critical rate-limiting steps involved in cancer metastasis due to its anti-adhesive, apoptosis-promoting, and apoptosis-inducing properties. Links: 'Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galectin-3 to promote metastasis by interaction with cancer-associated MUC1' https://academic.oup.com/carcin/article/35/12/2815/336118 'Appearance of peanut agglutinin in the blood circulation after peanut ingestion promotes endothelial secretion of metastasis-promoting cytokines' https://academic.oup.com/carcin/article/42/8/1079/6315265 'Pectins from various sources inhibit galectin-3-related cardiac fibrosis' https://www.sciencedirect.com/science/article/pii/S2452318621000477 Study: 'Modified citrus pectin stops progression of liver fibrosis by inhibiting galectin-3 and inducing apoptosis of stellate cells' URL: https://cdnsciencepub.com/doi/10.1139/cjpp-2015-0284 Study: 'Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3' URL: https://www.nature.com/articles/s41401-018-0004-z Study: 'Modified citrus pectin anti-metastatic properties: one bullet, multiple targets' URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782490/