Ep. 5: “Plasmodium Infection” Featuring Drs. Judy Lieberman and Caroline Junqueira

The Immunology Podcast

Guests:

Dr. Judy Lieberman is a Professor of Pediatrics at Harvard Medical School and holds an Endowed Chair in Cellular and Molecular Medicine at Boston Children’s Hospital. Dr. Caroline Junqueira is an Investigator at the Oswaldo Cruz Foundation and a visiting scientist at Harvard Medical School. Their recent research focuses on the role of γδ T cells in malaria.

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The Immunology Science Round Up

How Viruses Cause Pyroptosis – Bcl-2 members MCL-1 and BCL-xL sense translation inhibition during viral infection, leading to Gasdermin E-dependent pyroptosis.

Aging the Immune System – Researchers selectively deleted Ercc1, which encodes a crucial DNA repair protein, to increase senescence in the immune systems of mice, leading to systemic aging.

Thymic Development of Microbiota-Specific T Cells – Scientists showed that intestinal colonization in early life leads to the trafficking of microbial antigens from the intestine to the thymus by intestinal dendritic cells, which then induce the expansion of microbiota-specific T cells.

Antibody-Dependent Inflammation in COVID-19 – Researchers found that in patients with severe COVID-19, high titers and low fucosylation of anti-spike IgG leads to excessive inflammatory responses by alveolar macrophages.

Photo Reference: Courtesy of Drs. Judy Lieberman and Caroline Junqueira

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