Blood Vessel Organoids for Cruelty-Free Drug and Cosmetics Testing: Dr. Paul Bradfield, MesenFlow

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A drug that works for a mouse might not work for a human. How about testing drugs for inflammatory diseases – and cosmetics – on human organoids?
You’ll hear

• what are human vascular organoids
• and how to grow human cells

also about

• the mechanisms of inflammation and the ability to see where drugs can block it
• arthritis and other chronic inflammatory diseases
• personalized medicine
• cosmetics not tested on animals
• a terrifying process of founding a startup
• a death, a theft, a fire, and an obsessive mindset that kept the lab standing

Dr. Paul Bradfield is a scientist turned an efficient CEO. An expert in drug development and assay development, he has specialized in inflammatory diseases. After laboratory head at Merck Serono, he took an entrepreneurship path and founded MessenFlow.
MessenFlow is a Swiss scale-up that has developed a platform for animal-free accelerated drug and cosmetics development. Their human tissue engineering system mimics human inflammation and allows us to, literally, see the movement of leukocytes in blood vessels.
Here are more details about what the lab can do:
http://mesenflow.com
Timestamps:
0:00 Dr. Paul Bradfield and MesenFlow
1:12 What Are Organoids
4:59 Limits of Today's Pre-clinical Drug and Cosmetic Testing on Mouse Models
10:45 How to Build a System That Works Like a Human Inflammatory Pathology
14:57 Organoids for Chronic Inflammatory Diseases
16:48 Vascular Organoids and Recording White Blood Vessels Move
25:26 Testing a Drug on a Human Organoid Blood System
29:03 Organoids for Personalized Medicine
31:04 What's Leukocyte Recruitment and Transmigration
36:13 What's the Higher Throughpu
38:27 Pushed from Science to Disruptive Biotech Startup
47:20 Organoids for Cosmetics Testing
50:26 Terrifying Bootstrapped Startup Beginnings and Challenges
57:01 Scaling Up in the Field of Organoid Drug and Cosmetics Testing
59:58 Thank You, Follow MesenFlow
1:00:27 Follow X-Health.show, Disclaimer
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Chương

1. Dr. Paul Bradfield and MesenFlow (00:00:00)

2. What Are Organoids (00:01:12)

3. Limits of Today's Pre-clinical Drug and Cosmetic Testing on Mouse Models (00:04:59)

4. How to Build a System That Works Like a Human Inflammatory Pathology (00:10:45)

5. Organoids for Chronic Inflammatory Diseases (00:14:57)

6. Vascular Organoids and Recording White Blood Vessels Move (00:16:48)

7. Testing a Drug on a Human Organoid Blood System (00:25:26)

8. Organoids for Personalized Medicine (00:29:03)

9. What's Leukocyte Recruitment and Transmigration (00:31:04)

10. What's the Higher Throughput (00:36:13)

11. Pushed from Science to Disruptive Biotech Startup (00:38:27)

12. Organoids for Cosmetics Testing (00:47:20)

13. Terrifying Bootstrapped Startup Beginnings and Challenges (00:50:26)

14. Scaling Up in the Field of Organoid Drug and Cosmetics Testing (00:57:01)

15. Thank You, Follow MesenFlow (00:59:58)

16. Follow X-Health.show, Disclaimer (01:00:27)