079 - Dementia / Long COVID / No-Vax Tax

The Body of Evidence

What does the body of evidence have to say on the topic of dementia or, to use a more recent term, major cognitive disorder? Plus: what (little) we know about long COVID, and we go over arguments for and against the no-vax tax that was recently debated in Quebec.

Block 1:

(3:04) Dementia: types of memory

Block 2:

(11:53) Dementia: Alzheimer’s, ApoE, vascular dementia, Lewy body disease, frontotemporal dementia, how to screen for and diagnose dementia, treatments, vitamin E, ginkgo, Aduhelm, preventative measures

Block 3:

(32:32) Long COVID: prevalence, symptoms, scientific challenges, hypotheses, vaccination

Block 4:

(49:35) No-vax tax debate

* Jingle by Jillian Correia of Roctavio Canada

* Theme music: “Fall of the Ocean Queen“ by Joseph Hackl.

* Assistant researcher: Nicholas Koziris

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References:

1) Cochrane review on cholinesterase inhibitors: https://www.cochrane.org/CD001190/DEMENTIA_donepezil-people-dementia-due-alzheimers-disease

2) Cochrane review on memantine: https://www.cochrane.org/CD003154/DEMENTIA_memantine-treatment-dementi

3) Cochrane review on vitamin E: https://www.cochrane.org/CD002854/DEMENTIA_use-vitamin-e-treatment-mild-cognitive-impairment-and-alzheimers-disease-ad

4) Vitamin E and heart failure: https://pubmed.ncbi.nlm.nih.gov/15769967/

5) Vitamin E and mortality: https://pubmed.ncbi.nlm.nih.gov/15537682/

6) Ginkgo biloba: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003120.pub3/full

7) Aduhelm: https://www.nejm.org/doi/full/10.1056/NEJMp2111320

8) Jimmy Fallon and Paris Hilton on NFTs: https://youtu.be/5zi12wrh5So?t=222

9) Impossible MoCA: https://twitter.com/juliareillymd/status/1237531126723252225

10) Jonathan’s article on long COVID: https://www.mcgill.ca/oss/article/covid-19/debilitating-puzzle-box-long-covid

11) Post-COVID Care Centers: https://www.survivorcorps.com/pccc

12) Public Health Agency of Canada’s living systematic review on long COVID: https://www.medrxiv.org/content/10.1101/2021.06.03.21258317v2

13) Canadian paper on the experiences of people living with long COVID: https://www.medrxiv.org/content/10.1101/2022.01.20.22269617v1

14) Long COVID hypotheses: https://www.frontiersin.org/articles/10.3389/fmicb.2021.698169/full

Music Credits:

Heroic Trailer by Rafael Krux

Link: https://filmmusic.io/song/5359-heroic-trailer-

License: https://filmmusic.io/standard-license