LIVE: Ozempic and Alcoholism, Palos Verdes Landslide-The Wednesday Wrap

The Collier Landry Show

The Wednesday Wrap August 21, 2024

• Rancho Palos Verdes is sliding into the Ocean. Elon to the rescue?

• Ozempic, Wegovy, and other GLP-1 agonists show promising healthcare signs outside of weight loss.

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Additional Episode notes:

Intramural scientists at the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA), and collaborators from The Scripps Research Institute, found that semaglutide reduces alcohol consumption and binge-like drinking in a rodent model of alcohol misuse. Published in the June 2023 issue of the journal JCI Insight, the study adds to growing preclinical evidence that the glucagon-like peptide-1 (GLP-1) system plays a role in alcohol and other substance use disorders and that GLP-1 receptor agonists show potential for treating people with alcohol use disorder (AUD).

GLP-1 is a gut hormone that stimulates insulin secretion after eating. This promotes a feeling of fullness, helps regulate blood sugar, and reduces hunger cravings. Semaglutide and other GLP-1 agonists—medications that bind to GLP-1 receptors and mimic their effects—are currently used as treatments for diabetes and obesity.

“Parts of the brain that drive eating behaviors overlap extensively with the drive to use alcohol or other substances,” explained Lorenzo Leggio, M.D., Ph.D., and Leandro Vendruscolo, Pharm.D., Ph.D., two of the study's senior authors. They added that there is also an overlap between the brain mechanisms that regulate overeating and those that contribute to the development and maintenance of substance use disorders, including AUD.

Rancho Palos Verdes is a coastal city in south Los Angeles County, California. It sits atop the bluffs of the Palos Verdes Peninsula, neighboring three other cities in the Palos Verdes Hills: Palos Verdes Estates, Rolling Hills, and Rolling Hills Estates. Rancho Palos Verdes is known for its extensive nature preserves, hiking trails, school district, and high property values.

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