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The Straight and Marrow

Yvonne and Alex - Bone Marrow Transplant Specialist Nurses

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A show that discusses all things Allogeneic bone marrow transplant. From pre transplant considerations to survivorship using experiences of health care professionals patients & carers with current evidence to keep it straight. The Straight and Marrow podcast is sponsored by ARROW, the Bone Marrow Transplant Foundation.
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What would you do if you were diagnosed with cancer in your 20s or 30s? How would your life change? How would your friends and family react? Hopefully, you won't have to find out. But whether it’s cancer or something else, we all deal with pain, loss, and uncertainty in our lives. I'm Eliza Hale, and I'm the creator and host of this podcast. In each episode of Derailed, I'll sit down with someone who was diagnosed with cancer in their 20s or 30s. My interest in this topic is personal. Four y ...
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Most people don’t know that you’re considered a cancer survivor at the moment of diagnosis. It wasn’t always this way. Sixty years ago, a cancer diagnosis was a death sentence. And if you did survive, you were left to figure out the rest of your life on your own. But some survivors demanded something different, something better. This is The Cancer Mavericks, a deep-dive narrative into the people who fought for better treatment, forced doctors to listen, and pushed America to see the human si ...
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Waiting is the Hardest podcast is back with all new episodes! The goal of this podcast is to provide hope and healing to others by sharing stories of perseverance and triumph during difficult situations. Season 1 focused on one woman's story of survival following a near fatal car accident. Season 2 will focus on two young ladies healing of sickle cell disease following a bone marrow transplant. Share your story of waiting with us on social media or email us at waitingisthehardestpodcast@gmai ...
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Talking about all things sickle cell related, sharing warrior experiences and providing sickle cell related education. Support this podcast: https://podcasters.spotify.com/pod/show/thesicklecellpodcast/support
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Dr David Greene r3 Stem Cell

R3 Stem Cell Dr. David greene

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While running his pain clinic Dr. David Greene R3 Stem Cell became an expert in medical marketing eventually producing a book on the subject. In order to make the most of his time he dictated chapters while driving back and forth to business school. The book includes chapters on all of his marketing strategies for not only attracting new patients but also keeping them engaged over time.
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At Venkateshwar Hospital, state of the art technology and dedicated medical practitioners have been brought together under one roof for giving ethical medical care. Equipped with the most modern equipments and Information Technology, our practitioners work together as a team to provide the best possible treatment to our patients.
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I used to think that being a good dad was all about managing the chaos. Providing, being a good husband, feeding the dogs, volunteering at school, and making sure the homework gets done. And, if you can do all that in a nice suburban neighborhood, you're probably really doing well. I checked these boxes on most days and figured I was doing alright. Then, on Nov. 1, 2015, my daughter Galia said "Dad, my leg hurts." I thought it was nothing; it turns out it was something. Acute Myeloid Leukemi ...
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NSGC Podcast Series

National Society of Genetic Counselors

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The NSGC Podcast Series explores leading voices and best practices in genetic counseling. This podcast is produced by the National Society of Genetic Counselors. For more information on NSGC, please visit www.nsgc.org.
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Called to Care is a podcast by providers for providers. In each episode, we bring forward medical experts from Sanford Health to give fellow clinicians some advice and guidance they can use in their physician practice. Additionally, each physician expert featured in these episodes provides information about when it's time to refer patients and their families to more specialized care.
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Medical Miracles

Primedia Broadcasting

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Barbara Friedman presents ground breaking medical stories of South Africans from all walks of life, and the innovative medical teams that have brought about miracles to help them.
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Livonta Global

livontaglobal1

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The “Livonta Global Pvt.Ltd” is launched in India with a vision to expand its presence in every country making healthcare an easily accessible and affordable service by giving patients the “Right of Ownership to Choose and Decide” who, what, where, when and how much instead of making them unwillingly accept whatever is available. When the distance is not a concern and you are ready to travel halfway around the globe to an exotic and historic destination like India for Healthcare, Livonta Glo ...
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Prostate cancer is a type of cancer that particularly affects men (especially older men). Prostate cancer is classified in various stages. Early stages have a high cure rate, so early screening and detection are important to lead a healthy life. In the United States, the 5-year survival rate with prostate cancer is close to 98%. Many hospitals are offering the best cancer treatment in India to patients who are suffering from prostate cancer. In this context, you may consult with Livonta Glob ...
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Dr. David Greene R3 Stem Cell has been instrumental in advancing the use of R3 Stem Cell Therapy in the field of bone marrow transplants. His dedication to research and innovation has led to the development of effective, non-invasive treatments that are revolutionizing patient care. Dr. Greene's vision and expertise have not only expanded the poten…
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In this week's episode we’ll learn more about the role of ERG loss-of-function variants in bone marrow failure and hematological malignancies, a proposed pathway linking factor 11 activation to increased vascular permeability during inflammation, and new clinical criteria for diagnosing anemia, defining transfusion-dependence, and evaluating anemia…
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Five articles from the October 2024 issue summarized in five minutes, with the addition of a brief editorial commentary. The 5-in-5 feature is designed to give readers an overview of articles that may pique their interest and encourage more detailed reading. It may also be used by busy readers who would prefer a brief audio summary in order to sele…
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Dr. David Greene R3 Stem Cell is committed to improving treatment options for COPD and other chronic illnesses through novel medicines such as R3 Stem Cell Therapy. Dr. David Greene R3 Stem Cell aims to improve patient outcomes by providing the most effective therapy for each individual's specific needs. If you or a loved one suffers from COPD, tal…
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In this week's episode, we'll learn about the role of a platelet-specific glycoprotein receptor in abdominal aortic aneurysm formation, the influence of TP53 mutations on outcomes for patients with 5q-deleted myelodysplastic syndrome, and a rational combination treatment intended to produce more durable responses in patients with refractory B-cell …
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In this week's episode we'll learn about refining risk stratification in T-cell acute lymphoblastic leukemia, or ALL. After that, we'll discuss a novel gene therapy approach in severe alpha-thalassemia. Investigators describe an innovative mouse model and an effective gene therapy approach, renewing prospects for the development of novel strategies…
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Now, let's discuss how the promising solution - Dr. David Greene R3 Stem Cell Therapy works and manage this blood disorder. With intravenous infusion millions of stem cells are introduced into the patient's bloodstream. These stem cells enter the body and move to the bone marrow's injured areas, where they start to specialize and repair into new, h…
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In this week's episode we’ll discuss a novel tripartite fusion drives treatment resistance in acute promyelocytic leukemia. In some patients with atypical APL, these novel retinoic acid receptor gene fusions result in truncation of the ligand binding domain of the retinoic acid receptor protein, resulting in non-responsiveness to treatment with all…
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Regenerative treatments has advanced due to the man behind the innovation of R3 Stem Cell Therapy - Dr. David Greene R3 Stem Cell. He has helped many patients with spinal cord injury to take back the control of their lives. His knowledge, experience, expertise,and vision has made R3 Stem Cell Therapy a cutting-edge care for people suffering from th…
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In this week's episode we’ll discuss the safety and efficacy of pirtobrutinib with or without rituximab in relapsed/refractory CLL; learn more about erythroid 5ALA synthesis disorders and their conditional synthetic lethal dependency on pyridoxine; and discuss how targeting PKC alpha alleviates iron overload in diabetes and hemochromatosis through …
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In this episode, we explore the journey of aging with sickle cell disease through the inspiring stories of 80-year-old Ms. Pat McGill and Linda Wade. Ms. Pat shares her decades-long experience living with sickle cell, providing invaluable insight into the challenges and triumphs of aging with the condition. Linda Wade, founder of the Mark Thomas Fo…
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The management of pain after shoulder surgery typically includes the use of cryotherapy and the prescription of opioid analgesics. Much focus has been placed lately on the opioid epidemic, which in part is fueled by excessive prescription of opioid medication. Previous studies have found a combination of cryotherapy and compression effective at red…
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Five articles from the September 2024 issue summarized in five minutes, with the addition of a brief editorial commentary. The 5-in-5 feature is designed to give readers an overview of articles that may pique their interest and encourage more detailed reading. It may also be used by busy readers who would prefer a brief audio summary in order to se…
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In this week's episode we'll discuss outcomes following hematopoietic stem cell transplantation in pediatric patients with Fanconi anemia. Then, we'll learn about how new research shows that the transcription factor Foxo1, commonly associated with glucose metabolism, regulates hepcidin expression and systemic iron homeostasis. Finally, in Latin Ame…
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In this week's episode we’ll discuss how CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia; learn more about the effect of ATM germline pathogenic variants on the outcomes in children with ataxia-telangiectasia and hematological malignancies; and discuss the preclinical efficacy of a potent, selective m…
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Welcome to the first episode of Derailed. In this episode, Eliza sits down with her friend and fellow cancer survivor, Laura Adams. Laura was diagnosed with ovarian cancer when she was 26. In the almost decade since then, Laura has built a big and full life by accepting uncertainty and leaning into what feels true and right to her. Instagram: @dera…
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In this week's episode we'll discuss HA-1-targeted T-cell receptor T-cell therapy for recurrent leukemia after hematopoietic stem cell transplantation. Next, we'll learn about how 4D intravital imaging in mice reveals the key role of platelets as a source of procoagulant membranes in hemostasis. Finally, we'll hear about modifications to a common i…
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In this week's episode we’ll discuss the outcomes of younger patients with mantle cell lymphoma experiencing late relapse; learn more about mass spectrometry-based assessment of M-protein in peripheral blood during maintenance therapy in multiple myeloma and discuss in vivo CAR T-cell generation in non-human primates using lentiviral vectors. Featu…
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Introduced by Associate Editor Dr. Thomas Ortel, this bonus episode discusses the Review Series on Factor XI, published in volume 143 issue 15 of Blood Journal. Dr. Ortel is joined by contributing authors Owen McCarty, PhD, Gili Kenet, MD, and David Gailani, MD. Review Series Articles: Introduction to a review series on factor XI Biology of factor …
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Five articles from the August 2024 issue summarized in five minutes, with the addition of a brief editorial commentary. The 5-in-5 feature is designed to give readers an overview of articles that may pique their interest and encourage more detailed reading. It may also be used by busy readers who would prefer a brief audio summary in order to selec…
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Osteochondritis dissecans (OCD) of the humeral capitellum is a rare and challenging condition to treat. Several surgical options exist, but in the last few years, the pendulum has swung from debridement and microfracture to restoration of the articular surface. Osteochondral autografts from the rib and knee have been described, but donor-site morbi…
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In this week's episode we'll learn how cytomegalovirus infection early in life depletes preleukemic cells in a mouse model of B-cell acute lymphoblastic leukemia. After that we'll discuss new research, where GVHD targets organoid-forming bile duct stem cells in a TGF-beta-dependent manner. Conversely, a TGF-beta inhibitor protects these stem cells …
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For those seeking the best bone marrow transplant doctor in India, Venkateshwar Hospital is a leading choice. Renowned for its state-of-the-art facilities and expert medical team, the hospital offers comprehensive care for patients requiring bone marrow transplants. With a focus on patient safety and successful outcomes, Venkateshwar Hospital ensur…
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In this week's episode we'll learn about iron, HFE hemochromatosis, and infections. In this large, population-based study, both high and low levels of plasma iron and transferrin saturation were associated with increased risks of infection. Then, we'll discuss how bispecific antibodies improve CAR T-cell response in B-cell malignancies. In-vitro an…
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In this week's episode we’ll discuss how immune fitness impacts response to teclistamab in relapsed/refractory multiple myeloma; learn more about a new mechanism of resistance to asciminib conferred by the BCR::ABL1 M244V mutation, and discuss the impact of hematopoietic cell transplantation on myocardial fibrosis in young patients with sickle cell…
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In this week's episode we’ll discuss the safety and efficacy of decitabine in older patients with AML; learn how heme-induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice, and discuss the outcomes of treatment with HLA-mismatched HSCT with TCRab/CD19 lymphocyte depletion or post-HSCT cyclophosph…
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In this week's episode we'll discuss minimal residual disease as an intermediate clinical endpoint for multiple myeloma. Then, we'll learn about IPSS-R downstaging before transplant in MDS. Finally we'll hear about the connection between hereditary angioedema and venous thromboembolism. Featured Articles: EVIDENCE meta-analysis: evaluating minimal …
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A multicenter, double-blinded randomized controlled trial comparing isolated Bankart repair (NO REMP) to Bankart repair with remplissage (REMP) reported benefits of remplissage in reducing recurrent instability at 2 years postoperative. The ongoing benefits beyond this time point are yet to be explored. In conclusion, for the treatment of traumatic…
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Five articles from the July 2024 issue summarized in five minutes, with the addition of a brief editorial commentary. The 5-in-5 feature is designed to give readers an overview of articles that may pique their interest and encourage more detailed reading. It may also be used by busy readers who would prefer a brief audio summary in order to select …
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In this week's episode we’ll discuss the safety and efficacy of acalabrutinib, venetoclax and obinutuzumab in relapsed/refractory CLL; learn more about alternative donor transplantation for severe aplastic anemia and discuss clonal relapse dynamics in acute myeloid leukemia following allogeneic hematopoietic cell transplantation. Featured Articles:…
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In this week's episode we'll learn about the clinical benefit of complete remission with partial hematological recovery, or CRh, in patients with Acute Myeloid Leukemia (AML) treated with molecularly targeted drugs. Then we'll hear about a large cohort of patients with PNH were studied to detail PNH-related thrombotic events, unravel determinants o…
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In this week's episode we’ll discuss the mutational and transcriptional landscape of pediatric BCP lymphoblastic leukemia; learn more about the role of platelet-derived TGF-β1 in immune thrombocytopenia; and discuss the findings from a phase 3 trial of mavorixafor in WHIM syndrome. Featured Articles: Mutational and transcriptional landscape of pedi…
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In this week's episode we'll discuss new insights on the role of GM-CSF in establishing immune memory. The authors propose that the coordination of opposing immune memory programs, driven by GM-CSF, may be essential to efficient, yet controlled, innate immune responses. After that: Interleukin-1 inhibition in TTP. Researchers explore the potential …
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Introduced by Associate Editor Robert Zeiser, this Review Series focuses on the problem of immune escape by acute myeloid leukemia (AML). The series opens with a review of how AML escapes T-cell–driven elimination and then focuses on how p53 function impinges on AML recognition by immune cells. The series finishes with a summary of new approaches t…
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In this week's episode we’ll discuss the prognostic value of the Chronic Lymphocytic Leukemia International Prognostic Index in the era of targeted therapies, learn how peak ADAMTS13 activity can be used to assess ADAMTS13 conformation and risk of relapse in immune-mediated thrombotic thrombocytopenic purpura, and discuss the findings from a phase …
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In this week's episode we'll discuss assessing risk profile in Wiskott-Aldrich Syndrome, or WAS. Then, we'll learn about how the loss of DNMT3A confers resistance to interferon-alpha in hematopoietic stem cells carrying the JAK2-V617F mutation. Finally, we'll explore unrelated donor selection for AML patients undergoing hematopoietic stem cell tran…
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Join host Maia Garrison as she speaks with passionate advocates shining a light on sickle cell disease. La'Shardae Scott, the 2022 SCAY Advocate of the Year, discusses her non-profit organization that bridges the gap by transitioning pediatric patients to adult sickle cell care. Faith Adjei-Sarpong, the Digital SCAY Advocate of the Year, shares how…
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In this week's episode we’ll discuss the safety and efficacy of nilotinib with or without cytarabine in Philadelphia-positive acute lymphoblastic leukemia; learn more about thrombosis risk in double heterozygous carriers of Factor V Leiden and prothrombin G20210A and discuss the utility of circulating cell-free tumor DNA in prognostic prediction in…
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Five articles from the June 2024 issue summarized in five minutes, with the addition of a brief editorial commentary. The 5-in-5 feature is designed to give readers an overview of articles that may pique their interest and encourage more detailed reading. It may also be used by busy readers who would prefer a brief audio summary in order to select …
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Bone marrow stimulation (BMS) techniques such as microfracture, nanofracture, and the crimson duvet procedure expose the bone marrow of the proximal humerus to the rotator cuff tendon footprint. The effect of performing BMS on tendon healing is a subject of interest. In conclusion, the healing rate of rotator cuff repair was similar, regardless of …
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In this week's episode we'll learn about fitusiran prophylaxis in patients with hemophilia A or B, with or without inhibitors. Next we'll hear about new findings that heterozygous germline variants in the NBN gene that are linked to increased risk of B-cell acute lymphoblastic leukemia in children. Finally, we'll explore new insights on the histone…
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Snapping scapula syndrome (SSS) is a rare condition that is oftentimes debilitating. For patients whose symptoms are resistant to nonoperative treatment, arthroscopic surgery may offer relief. Because of the rarity of SSS, reports of clinical outcomes after arthroscopic SSS surgery are primarily limited to small case series and short-term follow-up…
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Join hosts Cassandra Trimnell and Maia Garrison as they hear from Holly John, Senior Director of Patient Advocacy at Agios Pharmaceuticals, recognized as the SCAY Community Partner of the Year for her groundbreaking work integrating patient voices into drug development and advocacy. Also, meet Ayana Johnson, the SCAY Youth Advocate of the Year, a h…
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In this week's episode we’ll discuss the effects of voxelotor on cerebral blood flow in pediatric sickle cell disease, learn more about venous and arterial thrombosis in patients with Vexas syndrome, and discuss differential sensitivity to tyrosine kinase inhibitors in ABL-class acute lymphoblastic leukemia. Featured Articles: The influence of voxe…
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In this week's podcast we'll discuss another step forward in stamping out high-risk myeloma. Then we'll hear about the plasmin-cleaved von Willebrand factor, or VWF, in microthrombosis. Finally we'll hear about new insights into the origins of sickle cell pain. Featured Articles: Daratumumab, carfilzomib, lenalidomide, and dexamethasone with tandem…
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In this week's episode we’ll discuss the utility of MRD in identifying patients with NPM1 AML who benefit from allogeneic transplant in first remission, learn more about the contribution of circulating hematopoietic stem/progenitor cell subsets to human hematopoietic hemostasis, and discuss the role of Let-7 miRNAs in regulation of BCL11A transcrip…
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Four articles from the May 2024 issue summarized in five minutes, with the addition of a brief editorial commentary. The 5-in-5 feature is designed to give readers an overview of articles that may pique their interest and encourage more detailed reading. It may also be used by busy readers who would prefer a brief audio summary in order to select t…
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In this week's epside we'll learn about ADAMTS recovery after caplacizumab therapy in patients with immune thrombotic thrombocytopenic purpura. Then, we'll hear about preclinical characterization of sonrotoclax, a potential second-generation BCL2 inhibitor. Finally we'll hear about new insights into the etiology of Castleman disease where researche…
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In this week's episode, we’ll discuss the findings from a study assessing responses after treatment with tisagenlecleucel [LM1] in adults with relapsed/refractory follicular lymphoma, learn more about the association between high microRNA-145 plasma levels and decreased risk of future incident venous thromboembolism, and discuss how epigenetic and …
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The decision and planning about when and how to return to work or study after an allogeneic BMT can be really stressful. Sometimes you really want to get back into it but you wonder what to tell your employer and colleagues. Then there's the decision about how many hours a day you can manage and how to juggle work, study, medical appointments and h…
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